Eight new germacranolides, minusolides A-H (-), along with two known analogues, and , were isolated from the whole plant of . Their structures were elucidated by spectroscopic analysis. Compounds and , and and are two pairs of rare epimers with opposite configurations at C-2 of the 2-methylbutyryloxy group. The absolute configurations were determined by X-ray diffraction studies. Compound exhibited cytotoxic activities against MDA-MB-231, A549, and HCT-116 cells with IC values of 6.1 ± 0.2, 8.4 ± 0.6, and 3.7 ± 0.6 μM, respectively. Compound induced the apoptosis of HCT-116 cells via suppression of PARP and promoting cleavage of PARP.
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