Thermal Load During Corneal Excimer Laser Ablation: Impact of Different Ablation Parameters.

Purpose: To characterize the impact of different ablation parameters on the change in peak corneal temperature during corneal excimer laser ablation.

Methods: Forty-two ablations were performed (21 on polymethylmethacrylate [PMMA] and 21 on porcine eyes) simulating photorefractive keratectomy (PRK), transepithelial PRK, and laser in situ keratomileusis (LASIK) treatments. Each ablation was recorded using infrared thermography. The change in peak corneal temperature was analyzed with respect to varying ablation parameters.

Results: Excellent correlation between the temperature rise in PMMA and porcine eyes was found. The change in peak corneal temperature was significantly higher in myopic than in hyperopic corrections, ranging from 6 °C for hyperopic corrections to 16 °C for a -18.00 diopters (D) correction. The change decreased with larger optical zones. Of all analyzed metrics, the refractive correction together with the maximum slope of the treatment showed the best coefficient of determination. Transepithelial ablations led to a higher change in peak corneal temperature than pure stromal ablations. Isothermal lines as a function of the refractive correction and optical zone diameter were calculated with a hypersurface model. If keeping the change in peak corneal temperature below 8 °C is the limit, only 3.00 to 4.00 D can be treated (6.5 mm or larger optical zone); for 10 °C, a maximum of 7.00 D (7 mm or larger optical zone) can be treated and for 12 °C, 10.00 D can be treated (6 mm or larger optical zone).

Conclusions: The effect of different parameters on change in peak corneal temperature during corneal laser ablation could be quantitatively evaluated. Cooling the cornea may aid in avoiding thermal denaturation. This is particularly important for transepithelial ablations, which further increase the thermal load due to the extra ablation of the epithelium. [J Refract Surg. 2020;36(10):667-676.].