AI Article Synopsis
- Prostate cancer is the most common cancer among men in sub-Saharan Africa, with increasing incidence and mortality rates observed in the region.
- An analysis of over 13,000 cases from 12 cancer registries showed significant increases in cancer risk and age-standardized incidence rates across most registries, particularly in Seychelles and Harare, Zimbabwe.
- This study highlights the rising rates of prostate cancer in sub-Saharan Africa, suggesting that factors like improved healthcare access and wider use of screening contribute to this trend, contrasting with global observations.
Article Abstract
Background: Prostate cancer is the leading cancer in men in sub-Saharan Africa (SSA) regarding incidence and mortality. Published data from a few registries in SSA suggest that the rates are still rising, but there is little comprehensive information on the time trends of prostate cancer incidence.
Methods: We analyzed registry data on 13,170 incident prostate cancer cases in men aged 40 years or above, from 12 population-based cancer registries in 11 SSA countries, with at least a 10-year time span of comparable data.
Results: We observed an increase in cumulative risks (CR) and age-standardized incidence rates (ASR) over time in all registries (statistically significant in all but one). The highest values of CR were found in Seychelles and Harare (Zimbabwe). The highest annual increase in the ASRs was seen in Seychelles and Eastern Cape (South Africa), whereas the lowest was seen in Mauritius. We mainly found a steady increase in incidence with age and during successive periods.
Conclusions: This analysis reveals that prostate cancer incidence rates are rising in many populations in SSA-often very rapidly-which is in contrast to recent observations worldwide. We acknowledge that the reasons are multifactorial and largely remain unclear, but believe that they are primarily associated with improvements in health care systems, for example, a broader use of prostate-specific antigen testing.
Impact: This study is the first to compare population-level data on time trends of prostate cancer incidence between multiple countries of SSA, presenting the different rates of increase in 11 of them.
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| http://dx.doi.org/10.1158/1055-9965.EPI-20-1005 | DOI Listing |
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