Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients. We collected serum and cerebrospinal fluid (CSF) from 43 iNPH patients and 35 with other neurodegenerative conditions, and serum from 43 healthy subjects. All samples were tested for AQP4-IgG/IgA/IgM antibodies using a live cell-based assay. No patients or controls had serum/CSF AQP4-IgG/IgA. One/43 iNPH patient and 0/43 controls tested positive for serum AQP4-IgM. The AQP4-IgM-positive iNPH patient had no clinico-radiological distinctive features. AQP4 antibodies are unlikely to play a role in iNPH pathogenesis.
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http://dx.doi.org/10.1016/j.jneuroim.2020.577407 | DOI Listing |
Brain Sci
January 2025
Scientific Institute, IRCCS E. Medea, Dipartimento/Unità Operativa Pasian di Prato, 33037 Pasian di Prato, Italy.
Background/objectives: Ventriculoperitoneal shunting is a validated procedure for the treatment of idiopathic normal-pressure hydrocephalus. To select shunt-responsive patients, infusion and tap tests can be used. Only gait is evaluated after the procedure to establish a potential improvement.
View Article and Find Full Text PDFFront Ophthalmol (Lausanne)
January 2025
Divison of Neuroradiology, Department of Radiology, University of Michigan, Ann Arbor, MI, United States.
Purpose: To investigate the presence and/or severity of cervicothoracic foraminal stenosis between the C7 and T3 segments could account for Horner syndrome, otherwise deemed to be idiopathic in nature.
Methods: This study was an IRB-approved, retrospective study that included 28 patients [mean ± standard deviation (age: 54.5 ± 18.
Proteomes
January 2025
Research & Development, AbbVie Bioresearch Center, Worcester, MA 01605, USA.
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial need in understanding IPF pathogenesis is identifying cell types associated with histopathological regions, particularly local fibrosis centers known as fibroblast foci. To address this, we integrated published spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) transcriptomics and adopted the Query method and the Overlap method to determine cell type enrichments in histopathological regions.
View Article and Find Full Text PDFWorld Neurosurg
January 2025
Radiology Department, Galilee Medical Center, Nahariya, 221001, Israel; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, 1311502, Israel.
Objective: This study was conducted to evaluate the time gap between earliest head CT with a significant Radscale score and ventriculo-peritoneal (VP) shunt placement.
Material And Methods: The study is a retrospective observational analytic study. The study population includes idiopathic normal pressure hydrocephalus (iNPH) patients treated with a VP shunt in a single center between the years 2016 and 2022 and have at least 2 CTs, one in proximity to diagnosis and another obtained at an earlier time point.
Acta Neurol Belg
January 2025
Department of Radiology, Health Sciences University Gulhane Faculty of Medicine, Ankara, Turkey.
Background: Trigeminal neuralgia is a disease characterized by severe facial pain that significantly reduces patients quality of life. Trigeminal neuralgia is subcategorized as idiopathic, classic or secondary. Magnetic resonance imaging is the basis for classification, but neurophysiological tests are also used.
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