Encephalopathy is emerging as a recurrent complication of COVID-19 yet remains poorly characterized. We report the case of a middle-aged woman with COVID-19-related encephalopathy presenting as expressive aphasia and inattentiveness, subsequently progressing to agitation and marked confusion. Brain MRI and CSF analysis were unremarkable, while EEG showed slowing with frontal sharp waves. Neuropsychiatric symptoms resolved following treatment with tocilizumab. CNS involvement in COVID-19 may present as a subacute encephalopathy characterized by prominent frontal lobe dysfunction, with language disturbances as first neurological manifestation. Future studies should further investigate the role of tocilizumab in treating COVID-19-related encephalopathy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513756 | PMC |
| http://dx.doi.org/10.1016/j.jneuroim.2020.577400 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessment of Post-COVID-19 Changes in Brain-Clinical and Imaging Evaluation Using MRI Vessel Wall Imaging and Complementary MRI Methods.
J Clin Med
November 2024
Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, 15-540 Białystok, Poland.
: The aim of the study was to evaluate the usefulness of vessel wall imaging and MRI in assessment of the post-COVID-19 changes in the brain. VWI is a progressive MRI technique that provides precise imaging of the pathological process in the wall of the vessel. It might help us to better understand the pathophysiology of COVID-19-related neurological lesions and may have an impact on management protocols.
View Article and Find Full Text PDFTreatment of cerebral venous thrombosis: a review.
Curr Med Res Opin
December 2024
The Aga Khan University, Neurology, Department of Medicine, Aga Khan University, Karachi, Pakistan.
Article Synopsis
- Cerebral venous thrombosis (CVT) is a rare type of stroke that may be linked to COVID-19 infection and vaccinations, with the management evolving to include fibrinolysis and mechanical thrombectomy.
- A literature review highlighted that low-molecular-weight heparin (LMWH) and unfractionated heparin (UH) are the recommended first-line treatments for acute CVT, while warfarin can be used later for prevention, although DOACs show promise as alternatives.
- Treatment approaches for COVID-19 related CVT are similar to non-COVID-19 CVT, but vaccine-related CVT requires different strategies involving non-heparin anticoagulants and possibly immunotherapy or steroids, emphasizing the
Mitochondrial dysfunction is a key feature of neurodegenerative diseases, often preceding symptoms and influencing disease progression. However, real-time imaging of mitochondria in the brain is limited by existing dyes like MitoTrackers, which struggle with poor tissue penetration, phototoxicity, and inability to cross the blood-brain barrier (BBB). This study introduces Cy5-PEG4, a novel mitochondrial-targeting dye that overcomes these limitations, enabling high-resolution, non-invasive imaging of mitochondrial dynamics.
View Article and Find Full Text PDFGambling on others' health: risky pro-social decision-making in the era of COVID-19.
Front Psychol
September 2024
Theory of Pain Laboratory, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland.
Introduction: In the early days of the COVID-19 pandemic, individuals were asked to perform costly actions to reduce harm to strangers, even while the general population, including authorities and experts, grappled with the uncertainty surrounding thenovel virus. Many studies have examined health decision-making by experts, but the study of lay, non-expert, individual decision-making on a stranger's health has been left to the wayside, as ordinary citizens are usually not tasked with such decisions.
Methods: We sought to capture a snapshot of this specific choice behavior by administering two surveys to the general population in the spring of 2020, when much of the global community was subject to COVID-19-related restrictions, as well as uncertainty surrounding the virus.
Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network analyses.
Eur Neuropsychopharmacol
January 2025
Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA; The Zucker Hillside Hospital, Northwell Health, New York, USA; Feinstein Institutes for Medical Research, Center for Psychiatric Neuroscience, Manhasset, New York, USA. Electronic address:
Article Synopsis
- The COH-FIT study is a large, multi-country survey aimed at identifying factors affecting wellbeing and mental health outcomes during the COVID-19 pandemic, involving a representative sample of 121,066 adults.
- Researchers analyzed both modifiable (like coping strategies and pre-pandemic stress) and non-modifiable factors (such as age, gender, and socioeconomic status), finding significant negative effects on wellbeing and psychopathology scores during the pandemic.
- The study identified 15 modifiable and 9 non-modifiable risk factors, alongside 13 modifiable and 3 non-modifiable protective factors, emphasizing the importance of social support and coping strategies in mental health outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!