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Introduction: Benralizumab is an interleukin 5-receptor-blocking drug registered for the treatment of eosinophilic asthma. It has proven efficient and safe in a small phase-II trial in hypereosinophilic syndrome and is currently being investigated in a larger, randomized phase-III trial. We report on real-world experience with benralizumab in 15 patients with severe Hypereosinophilic syndrome (HES) that were refractory to other treatments or on unacceptable steroid doses.
View Article and Find Full Text PDFThe diagnosis of eosinophilic granulomatosis with polyangiitis has been 'masked' by asthma: a case report.
AME Case Rep
December 2024
The PLA Center of Respiratory and Allergic Disease Diagnosing Management, General Hospital of Northern Theater Command, Shenyang, China.
Background: Patients with asthma exhibit a significantly heightened susceptibility to eosinophilic granulomatosis with polyangiitis (EGPA) when compared to the general population. Vigilance for EGPA manifestations is crucial, especially in cases where asthma remains poorly controlled despite high-dose corticosteroid therapy or when eosinophil counts exceed 5%. The diagnosis of EGPA can be complex due to the absence of definitive biomarkers, as indicated by the American College of Rheumatology (ACR)'s 1990 classification criteria.
View Article and Find Full Text PDFA Case of Kimura Disease in the Left Postauricular and Neck Region.
Ear Nose Throat J
January 2025
Department of Otolaryngology, People's Hospital of Jingshan, Jingshan Union Hospital of Huazhong University of Science and Technology, Jingmen City, Hubei Province, People's Republic of China.
This case involved a 21-year-old male patient who was admitted due to having a lump behind the left ear that had been present for 2 years and had gradually increased in size for over a year. This was accompanied by palpable hard masses on the same side of the neck. Laboratory tests indicated an elevated eosinophil count, and magnetic resonance imaging confirmed the "string-of-beads" sign in the left cervical lymph nodes.
View Article and Find Full Text PDFEosinophilic dermatitis in a patient with chronic lymphocytic leukemia.
Indian J Pathol Microbiol
January 2025
Department of Medical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India.
Hematological malignancies are known to have cutaneous manifestations, either in the form of direct infiltration of skin by malignant cells or as a result of paraneoplastic syndrome. Many hematological malignancies, including chronic lymphocytic leukemia (CLL), are known to cause malignancy-induced Eosinophilic Dermatoses. We present a case of an elderly woman who presented with multiple pruritic patches.
View Article and Find Full Text PDFEvaluation of an automated assay for eosinophil-derived neurotoxin in serum.
Clin Biochem
January 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United states. Electronic address:
Introduction: Eosinophil-derived neurotoxin (EDN) is a promising biomarker for eosinophil activation during inflammatory responses. Here we evaluate the analytical performance of an automated fluorescence enzyme immunoassay for EDN in serum and explore its relationship with eosinophil counts in both healthy participants and those with eosinophilic conditions.
Materials And Methods: Paired serum samples were collected from individuals for whom a complete blood count with differential was ordered.
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