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Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes. | LitMetric

AI Article Synopsis

  • Aberrant redox signaling plays a key role in chronic metabolic diseases like type 2 diabetes (T2D), and current methods to restore balance have had limited results.
  • A new study shows that using static magnetic and electric fields can noninvasively enhance the body’s redox environment, leading to improved insulin sensitivity and glucose control in T2D mouse models within just three days.
  • This approach reduces harmful effects from oxygen metabolism by altering mitochondrial function, suggesting a promising noninvasive treatment method for T2D and similar redox-related diseases.

Article Abstract

Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic redox homeostasis have had limited success. A noninvasive, sustained approach would enable the long-term control of redox signaling for the treatment of T2D. We report that static magnetic and electric fields (sBE) noninvasively modulate the systemic GSH-to-GSSG redox couple to promote a healthier systemic redox environment that is reducing. Strikingly, when applied to mouse models of T2D, sBE rapidly ameliorates insulin resistance and glucose intolerance in as few as 3 days with no observed adverse effects. Scavenging paramagnetic byproducts of oxygen metabolism with SOD2 in hepatic mitochondria fully abolishes these insulin sensitizing effects, demonstrating that mitochondrial superoxide mediates induction of these therapeutic changes. Our findings introduce a remarkable redox-modulating phenomenon that exploits endogenous electromagneto-receptive mechanisms for the noninvasive treatment of T2D, and potentially other redox-related diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819711PMC
http://dx.doi.org/10.1016/j.cmet.2020.09.012DOI Listing

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