To investigate the effect of a new platform of nanocarriers, called nanodroplets (NDs), to enhance the activity of vancomycin (Vm), against bacterial colonies isolated from chronic ulcers of the lower limbs. Oxygen-loaded nanodroplets (OLNDs) or oxygen-free nanodroplets (OFNDs) were loaded with Vm (Vm-OLNDs and Vm-OFNDs). MIC and minimal bactericidal concentrations were evaluated for Vm, OLNDs and OFNDs loaded with Vm, OLNDs and OFNDs. Nanodroplets, either with or without oxygen, appeared as a suitable platform of antibiotic nanocarriers to enhance the antibacterial effects of Vm against , with a decrease in both MIC and minimal bactericidal concentration against Vm-resistant strains.
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| http://dx.doi.org/10.2217/fmb-2019-0255 | DOI Listing |
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