Wearable exercise trackers provide data that encode information on individual running performance. These data hold great potential for enhancing our understanding of the complex interplay between training and performance. Here we demonstrate feasibility of this idea by applying a previously validated mathematical model to real-world running activities of ≈ 14,000 individuals with ≈ 1.6 million exercise sessions containing duration and distance, with a total distance of ≈ 20 million km. Our model depends on two performance parameters: an aerobic power index and an endurance index. Inclusion of endurance, which describes the decline in sustainable power over duration, offers novel insights into performance: a highly accurate race time prediction and the identification of key parameters such as the lactate threshold, commonly used in exercise physiology. Correlations between performance indices and training volume and intensity are quantified, pointing to an optimal training. Our findings hint at new ways to quantify and predict athletic performance under real-world conditions.
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http://dx.doi.org/10.1038/s41467-020-18737-6 | DOI Listing |
Sports Med Open
January 2025
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.
Background: Little is known about the lower extremity muscle co-contraction patterns during sprinting and its relation to running velocity (i.e., performance).
View Article and Find Full Text PDFDrug Saf
January 2025
Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Natural language processing (NLP) and machine learning (ML) techniques may help harness unstructured free-text electronic health record (EHR) data to detect adverse drug events (ADEs) and thus improve pharmacovigilance. However, evidence of their real-world effectiveness remains unclear.
Objective: To summarise the evidence on the effectiveness of NLP/ML in detecting ADEs from unstructured EHR data and ultimately improve pharmacovigilance in comparison to other data sources.
Alzheimers Dement
December 2024
Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Background: Alzheimer's disease (AD) pathophysiology is complex and not completely known. Emerging new biomarkers that evaluate synaptic function (VILIP-1, neurogranin), co-pathology (alpha-synuclein), and neurodegeneration (NFL) are potential candidates to be incorporated into the early AD diagnosis. To better understand the relevance of these biomarkers, we evaluated the correlations between their CSF concentrations with whole-brain grey matter volumes in SCD and MCI, according to their amyloid status (A- or A+).
View Article and Find Full Text PDFBackground: Previous studies have documented age-related changes in behavior and cognitive functions and investigated the molecular changes in aging brain using inbred mouse strains such as C57BL/6, BALB/c etc. In this study using a genetically heterogenous mouse population (UM-HET3) we investigated age-related changes in motor and memory functions and their association with blood cell measures.
Method: Both male and female UM-HET3 mice at age of 11 months (middle-aged) and 25 months (old) were used in this study.
Alzheimers Dement
December 2024
Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Background: Alzheimer's disease (AD) pathophysiology is complex and not completely known. Emerging new biomarkers that evaluate synaptic function (VILIP-1, neurogranin), co-pathology (alpha-synuclein), and neurodegeneration (NFL) are potential candidates to be incorporated into the early AD diagnosis. To better understand the relevance of these biomarkers, we evaluated the correlations between their CSF concentrations with whole-brain grey matter volumes in SCD and MCI, according to their amyloid status (A- or A+).
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