Background: Less-invasive surfactant administration (LISA) is increasingly used. We investigated the feasibility of a new LISA-device (Neofact®) in neonates.
Design: Prospective observational pilot study with open-label LISA in two tertiary neonatal intensive care units.
Patients: 20 infants with a gestational age of ≥26+0/7 weeks and an indication for LISA (Respiratory Severity Score (RSS)≥5 or fraction of inspired oxygen (FiO) ≥0.30). Infants with respiratory tract malformations or unavailability of an instructed neonatologist were excluded.
Main Outcome Measures: Success of LISA, defined as laryngoscopy-confirmed intratracheal catheter position or a decrease in FiO by ≥0.05 or to 0.21, accompanied by an RSS decrease of ≥2; number of attempts needed for tracheal catheterisation.
Results: 20/57 screened infants were enrolled. Successful application occurred in 19/20 (95%). One application failed after three attempts. No device-related adverse events occurred. The median number of attempts was 2, success rate per attempt 19/31 (61%).
Conclusion: LISA via Neofact® appears feasible.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907548 | PMC |
| http://dx.doi.org/10.1136/archdischild-2020-319792 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surfactant administration and cerebral oxygenation and perfusion in preterm neonates - A systematic review of literature.
Paediatr Respir Rev
December 2024
Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Cerebral Development and Oximetry.
Background: Surfactant replacement is standard for preterm neonates with respiratory distress syndrome, improving survival and outcomes. Less invasive surfactant administration (LISA) and intubation-surfactant-extubation (INSURE) are preferred methods for surfactant replacement in spontaneously breathing preterm neonates. Despite the undeniable benefits of surfactant implementation in neonatal care, surfactant administration can affect vital parameters and cerebral oxygenation and perfusion, assessed by near-infrared spectroscopy (NIRS).
View Article and Find Full Text PDFApplication of a new type of double-lumen endotracheal tube in preterm infants with respiratory distress syndrome: study protocol for a non-inferiority randomised controlled trial (NISA).
BMJ Open
December 2024
Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, Chongqing, China.
Background: Non-invasive ventilation combined with pulmonary surfactant (PS) therapy is recognised as a method for treating neonatal respiratory distress syndrome (NRDS). Among the administration, methods of PS, INtubation-SURfactant-Extubation (InSurE) and less invasive surfactant administration (LISA) have been widely discussed.LISA technique prevents patients from exposure to invasive positive pressure ventilation (PPV), thus improving the long-term outcomes of the respiratory system, but it faces challenges in resource-limited areas due to complexity and cost.
View Article and Find Full Text PDFReply to Letter to the Editor by Maiwald et al. on "Less Invasive Surfactant Administration for Preterm Infants - State of the Art".
Neonatology
November 2024
Department of Pediatrics, University Hospital Lübeck, Lübeck, Germany.
Outcomes, safety and health economics of introduction of video laryngoscopy-assisted less invasive surfactant administration.
J Perinatol
November 2024
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, Northwell Health, New Hyde Park, NY, USA.
Article Synopsis
- Less invasive surfactant administration (LISA) using video-laryngoscopy (VL) shows improved outcomes in premature infants compared to traditional InSurE methods.
- A study comparing 67 infants receiving VL-assisted LISA to 52 receiving InSurE found shorter non-invasive ventilation times, lower oxygen therapy duration, and fewer overall hospital costs in the VL group.
- The results suggest that VL-assisted LISA is not only safer with a high success rate in tracheal catheter placement but also leads to better resource efficiency in neonatal care for infants ≥29 weeks gestational age.
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study.
Paediatr Drugs
November 2024
Department of Neonatology, Shamir Medical Center, Zerifin, Israel.
Introduction: Less invasive surfactant administration (LISA) involves delivering surfactant to a spontaneously breathing infant by passing a thin catheter through the vocal cords and has become the preferred method for surfactant delivery. However, the role of pre-LISA sedation remains unclear.
Objective: The aim of this study was to describe the use of dexmedetomidine for LISA in preterm and early-term infants.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!