Milk and dairy foods are naturally rich sources of a wide range of nutrients, and when consumed according to recommended intakes, contribute essential nutrients across all stages of the life cycle. Seminal studies recommendations with respect to intake of saturated fat have been consistent and clear: limit total fat intake to 30% or less of total dietary energy, with a specific recommendation for intake of saturated fat to less than 10% of total dietary energy. However, recent work has re-opened the debate on intake of saturated fat in particular, with suggestions that recommended intakes be considered not at a total fat intake within the diet, but at a food-specific level. A large body of evidence exists examining the impact of dairy consumption on markers of metabolic health, both at a total-dairy-intake level and also at a food-item level, with mixed findings to date. However the evidence suggests that the impact of saturated fat intake on health differs both across food groups and even between foods within the same food group such as dairy. The range of nutrients and bioactive components in milk and dairy foods are found in different levels and are housed within very different food structures. The interaction of the overall food structure and the nutrients describes the concept of the 'food matrix effect' which has been well-documented for dairy foods. Studies show that nutrients from different dairy food sources can have different effects on health and for this reason, they should be considered individually rather than grouped as a single food category in epidemiological research. This narrative review examines the current evidence, mainly from randomised controlled trials and meta-analyses, with respect to dairy, milk, yoghurt and cheese on aspects of metabolic health, and summarises some of the potential mechanisms for these findings.
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http://dx.doi.org/10.3390/nu12103040 | DOI Listing |
Mol Med Rep
May 2025
Department of Dermatology, College of Medicine, Chung‑Ang University, Seoul 06974, Republic of Korea.
Natural killer (NK) cells produce various cytokines, including interleukin (IL)‑1β, IL‑6, IL‑10, IL‑12, interferon γ, tumor necrosis factor α and transforming growth factor β, which are critical in modulating immune responses. NK cell‑conditioned medium (NK‑CdM), rich in cytokines, has potential applications in therapy and healing. The present study aimed to investigate the protective effect of NK‑CdM against ultraviolet B (UVB)‑mediated photoaging using and models.
View Article and Find Full Text PDFBirth Defects Res
March 2025
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Introduction: Hormone pregnancy tests (HPTs), containing synthetic progesterone and oestrogen, were used to diagnose pregnancy in the 1950s to early 1980s. An existing pregnancy was purported to be unaffected while expulsion of the uterine lining (withdrawal bleed) was supposed to occur if the woman was not pregnant. However, studies in the 1960s-1980s associated HPTs with teratogenicity and some countries banned their use in the early 1970s.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
March 2025
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Background: Papillary thyroid carcinoma (PTC) is a common endocrine tumor with a rapidly increasing incidence. While surgery and radioactive iodine treatment are effective for most patients, they impose significant economic and psychological burdens. Metabolic dysregulation, particularly in fatty acid metabolism (FAM), plays a critical role in cancer progression and immune responses.
View Article and Find Full Text PDFJ Lipids
February 2025
Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, Japan.
Lipids are the most abundant biomolecules of human plasma, and their balance plays a significant role in health and disease management. Despite the importance of lipids, the studies focused on the comprehensive determination of the plasma lipidome in children are limited. In this study, we investigated the sex, age, and weight-specific changes in the plasma lipidome of nonfasting preadolescent children aged 9-12 years ( = 342) using a nontargeted liquid chromatography-mass spectrometry technique.
View Article and Find Full Text PDFNeurohospitalist
March 2025
Department of Neurology, Welcare Hospital, Kochi, Kerala.
Intracranial lipomas are rare congenital malformations which are neither hamartomas nor true neoplasms. Rarely lipomas show blooming on susceptibilty weighted images and this can be confused with subacute blood especially if the patient present with headache and MRI brain is the only available image. Do fat saturated images or CT scan if T1 weighted MRI brain shows hyperintensity along with blooming on susceptibilty weighted images.
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