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PEGylated CuInS/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75/MAPK pathway. | LitMetric

PEGylated CuInS/ZnS quantum dots inhibit neurite outgrowth by downregulating the NGF/p75/MAPK pathway.

Ecotoxicol Environ Saf

Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, Shenzhen Key Lab of Synthetic Biology, Department of Physiology, School of Basic Medical Sciences Shenzhen University, Shenzhen, 518055, China. Electronic address:

Published: January 2021

AI Article Synopsis

Article Abstract

The widespread application of cadmium-free CuInS/ZnS QDs has raised great concern regarding their potential toxicity to humans. To date, toxicological data related to CuInS/ZnS QDs are scarce. Neurons play extraordinary roles in regulating the activities of organs and systems, and serious consequences occur when neurons are damaged. Currently, the potential toxicity of CuInS/ZnS QDs on neurons has not been fully elucidated. Here, we investigate the neurotoxicity of PEGylated CuInS/ZnS (CuInS/ZnS-PEG) QDs on neuron-like PC12 cells. We found that CuInS/ZnS-PEG QDs were taken up by PC12 cells, but at a concentration range from 0 to 100 μg/mL, they did not affect the survival rate of the PC12 cells. In addition, we found that CuInS/ZnS-PEG QDs significantly inhibited neurite outgrowth from and the differentiation of PC12 cells in the presence of NGF, while COOH-modified CuInS/ZnS QDs or free PEG did not have a similar effect. Further studies showed that CuInS/ZnS-PEG QDs obviously downregulated the expression of low-affinity NGF receptor (p75) and subsequently negatively regulated the downstream MAPK cascade by dephosphorylating ERK1/2 and AKT. Taken together, these results suggest that CuInS/ZnS-PEG QDs disturb NGF signal transduction from external stimuli to relevant internal signals, thus affecting normal biological processes such as neurite outgrowth and cell differentiation.

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Source
http://dx.doi.org/10.1016/j.ecoenv.2020.111378DOI Listing

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