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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831642PMC
http://dx.doi.org/10.1016/j.jaad.2020.09.086DOI Listing

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Article Synopsis
  • This systematic review aimed to analyze the prevalence and characteristics of skin manifestations associated with COVID-19, as these can assist in diagnosis, especially since the details were unclear.
  • The review included 31 studies with over 10,000 patients and found that the overall prevalence of skin manifestations was about 29%, predominantly observed in Africa, with hands, feet, and trunk being most affected.
  • Patients with milder COVID-19 symptoms showed more specific skin conditions compared to those with severe cases, indicating that skin assessments should be a key part of evaluating and diagnosing COVID-19, particularly in adults and the elderly.
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Aicardi-Goutières syndrome (AGS) is a rare genetic disorder that primarily affects the central nervous system and is characterized by severe intellectual and physical disabilities. Although AGS traditionally exhibits nonpsychiatric symptoms, our case challenges this norm by presenting an 18-year-old male with AGS who developed distinctive psychiatric manifestations that required hospital admission.The patient, diagnosed with spastic cerebral palsy and thrombotic vasculopathy, displayed abrupt behavioral disturbances, insomnia, and food aversion.

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Objective: To evaluate background incidence rates of 59 health outcomes of interest (HOI) in a diverse population, including important subpopulations, during the pre-COVID-19 era (1 January 2017-31 December 2019) and the COVID-19 era (1 March 2020-31 December 2020), before the introduction of COVID-19 vaccines.

Design: Observational retrospective cohort study. Annual incidence rates and 95% confidence intervals (CIs) of HOIs were estimated for each population of interest, stratified by: age, sex, age and sex and seasonality.

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This case series describes the clinical course and reconstructive methods utilized for patients with diabetes and significant gangrene and necrosis following coronavirus disease 2019 (COVID-19) infection. COVID-19 produces mainly respiratory symptoms but has a variety of atypical presentations and sequelae. Serious complications are increased in patients with underlying medical conditions such as diabetes mellitus.

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Article Synopsis
  • COVID-19, caused by the SARS-CoV-2 virus, primarily presents with respiratory symptoms, fever, and chills, but it can also cause skin-related issues in some patients.
  • Dermatological symptoms include various types of lesions, such as chilblain-like, maculopapular, and necrotic lesions, but the exact reasons for these skin reactions remain unclear.
  • The review seeks to gather and analyze past studies and case reports to better understand these skin manifestations and identify areas for future research.
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