Background/aim: Coronavirus 2019 disease (Covid-19) was first seen in December 2019 and afterwards it became pandemic. Several systemic involvements have been reported in Covid-19 patients. In this study, it was aimed to investigate the cerebrovascular hemodynamics in patients with Covid-19.
Materials And Methods: The sample of this study included 20 patients hospitalized in our clinic diagnosed with Covid-19 via PCR modality and 20 healthy volunteers of similar age and sex. Bilateral middle cerebral arteries were investigated with transcranial Doppler ultrasonography. Basal cerebral blood flow velocities and vasomotor reactivity rates were determined and statistically compared.
Results: When patient and control groups were compared, the mean blood flow velocity was found to be higher in Covid-19 patients than in the healthy volunteers and it was statistically significant (P = 0.00). The mean vasomotor reactivity rates values were found to be lower in the Covid-19 group than the healthy group and was also statistically significant (P = 0.00).
Conclusion: An increase in basal cerebral blood velocity and a decrease in vasomotor reactivity rates in patients with Covid-19 can be considered as an indicator of dysfunction of cerebral hemodynamics in the central nervous system and this can be evaluated as a result of endothelial dysfunction.
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http://dx.doi.org/10.3906/sag-2006-203 | DOI Listing |
Methods Mol Biol
December 2024
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vasomotor function (constriction, dilation) can be assessed ex vivo using the pressure myograph technique, also referred to as perfusion myography in older literature. The technique involves isolating an artery (or any other blood vessel/lymphatic vessel) from an animal research model or from surgery-resected human tissue. The vessel preparation is mounted between two tiny glass pipettes through which a physiological saline solution (usually Krebs') is perfused while superfusing the preparation with the same solution.
View Article and Find Full Text PDFMicrovasc Res
January 2025
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing 100005, China. Electronic address:
Clin Auton Res
October 2024
Institute of Psychology, UMIT Tirol-University of Health Sciences and Technology, Hall in Tirol, Austria.
Purpose: Alterations of autonomic cardiovascular control are implicated in the origin of chronic low blood pressure (BP) (hypotension), but comprehensive analysis of baroreflex function is still lacking. This study explored baroreflex function in its cardiac, vascular and myocardial branches METHODS: Continuous BP was recorded at rest and during a mental arithmetic task in 40 hypotensive and 40 normotensive participants. Assessed cardiovascular variables included stroke volume (SV) (calculated by the Modelflow method), heart rate (HR), cardiac output (CO), total peripheral resistance (TPR) and heart rate variability (HRV).
View Article and Find Full Text PDFInt J Mol Sci
September 2024
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli, Italy.
Methamphetamine (METH) is a drug of abuse, which induces behavioral sensitization following repeated doses. Since METH alters blood pressure, in the present study we assessed whether systolic and diastolic blood pressure (SBP and DBP, respectively) are sensitized as well. In this context, we investigated whether alterations develop within A1/C1 neurons in the vasomotor center.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
December 2024
Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, United States.
The cerebral vasodilator response to increased arterial carbon dioxide (CO) concentration, termed cerebral vasomotor reactivity (CVMR), is used to assess cerebral vascular function. We sought to assess the within-day and between-day repeatability of CVMR to rebreathing-induced hypercapnia. Twelve healthy adults performed a protocol (17 ± 2 min between trials), ten performed protocol (145 ± 16 min between trials), and seventeen performed a protocol (5 ± 2 days between visits).
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