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Challenges in Differential Diagnosis of Diffuse Gingival Enlargement: Report of Two Representative Cases and Literature Review.
Dent J (Basel)
December 2024
Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens (NKUA), 11527 Athens, Greece.
The etiology of diffuse gingival enlargement is multifactorial, and the definitive diagnosis may be challenging. To highlight the nuances of the differential diagnosis, we present two cases of generalized gingival overgrowth and discuss the diagnostic dilemmas. In the first case, an 82-year-old male with a medical history of hypertension and prostatitis had a chief complaint of symptomatic oral lesions of a 20-day duration, accompanied by fever and loss of appetite.
View Article and Find Full Text PDFThe impact of volume of dissolution medium for biopredictive dissolution/permeation studies of enabling formulations: A comparison of two brands of telmisartan / amlodipine tablets.
J Pharm Sci
December 2024
Department of Physics Chemistry and Pharmacy, University of Southern Denmark, SDU, FKF, Campusvej 52, Odense, 5230, Denmark. Electronic address:
For compendial dissolution testing of solid dosage forms, media volumes of 500 to 900 mL are used in apparatus I and II to ensure sink conditions. However, these volumes are considerably larger than those in the gastrointestinal tract. Thus, the experiments are not biomimetic and possibly not suitable for biopredictive dissolution testing.
View Article and Find Full Text PDFEnhancing the practicality along with greenness sustainability of a high throughput HPLC-MS/MS bioanalytical method for the simultaneous determination of amlodipine, perindopril, and its active metabolite perindoprilat in human plasma: Application to a pharmacokinetic study.
J Chromatogr A
January 2025
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., Cairo 11562, Egypt. Electronic address:
Numerous studies have demonstrated the benefits of amlodipine and perindopril combination therapy in decreasing blood pressure and improving outcomes for high-risk patients. In order to assess the pharmacokinetics of the 2 drugs along with perindoprilat; the active metabolite of perindopril, a simultaneous LC-MS/MS quantification method of amlodipine (AML), perindopril (PER) and perindoprilat (LAT) in human plasma has been developed and validated using amlodipine D4, perindopril D4 and perindoprilat D4 as internal standards (ISs), respectively. A simple and fast protein precipitation method was used to analyze the three analytes from KEDTA human plasma.
View Article and Find Full Text PDFExploring Sex, Gender, and Gender-Related Sociocultural Factors in Clinical Decision-Making for Older Adults Using a Prescribing Cascade Vignette: A Transnational Qualitative Study.
Drugs Aging
December 2024
Women's Age Lab, Women's College Hospital, Toronto, ON, Canada.
Background: Despite growing awareness of sex differences in inappropriate prescribing among older adults, including the initiation of problematic prescribing cascades, the impact of gender bias remains largely unexplored.
Objectives: We explored how a patient's sex and gender-related sociocultural factors influence physicians' prescribing decisions, potentially leading to prescribing cascades in older adults. A secondary objective was to explore whether and how physician sex affected prescribing decisions for female and male patients.
Nephrotic Syndrome Complicated by Pulmonary Embolism and Inferior Vena Cava Thrombosis: A Case Report.
Cureus
October 2024
Faculty of Medicine, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, GBR.
Article Synopsis
- A 52-year-old man presented to the emergency department with chest pain and shortness of breath, leading to a CT scan that revealed a right pulmonary embolism and inferior vena cava thrombus.
- Following the diagnosis, the patient started emergency anticoagulant therapy and was later diagnosed with nephrotic syndrome (NS).
- A renal biopsy confirmed minimal change disease, which resolved on its own, underscoring the serious nature of NS as it can first manifest through significant venous blood clots.
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