AI Article Synopsis
- In a mouse model of malaria, infection triggers significant changes in the body’s metabolism and immune response during both sickness and recovery.* -
- The study found that metabolite increases activate the aryl hydrocarbon receptor (AHR), which plays a key role in modulating the immune response.* -
- Mice with higher AHR activity showed greater susceptibility to malaria and suffered from severe health issues, indicating that AHR helps protect against tissue damage during infection.*
Article Abstract
Systemic metabolic reprogramming induced by infection exerts profound, pathogen-specific effects on infection outcome. Here, we detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria. We describe extensive alterations in metabolism during acute infection, and identify increases in host-derived metabolites that signal through the aryl hydrocarbon receptor (AHR), a transcription factor with immunomodulatory functions. We find that mice are more susceptible to malaria and develop high plasma heme and acute kidney injury. This phenotype is dependent on AHR in -expressing radioresistant cells. Our findings identify a role for AHR in limiting tissue damage during malaria. Furthermore, this work demonstrates the critical role of host metabolism in surviving infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538157 | PMC |
| http://dx.doi.org/10.7554/eLife.60165 | DOI Listing |
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