Step and redox efficient nitroarene to indole synthesis.

Chem Commun (Camb)

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.

Published: November 2020

Step and redox efficiencies are a rising priority in synthetic method development, in order to make synthetic processes more sustainable and more affordable. Herein, a step and redox efficient nitroarene to indole synthesis is developed, in sharp contrast to the rich literature on the construction of indoles. Elemental zinc was found to be the best terminal reductant.

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http://dx.doi.org/10.1039/d0cc03258aDOI Listing

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