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http://dx.doi.org/10.1016/j.annals.2020.103056 | DOI Listing |
Adv Biol (Weinh)
December 2024
International Corporation Laboratory of Agriculture and Agricultural Products Safety, Yangzhou University, Yangzhou, 225009, China.
The use of antibiotics is the preferred therapy for bacterial diseases. However, overusing antibiotics has led to the development of antibiotic resistance in bacteria, which is now a major public health concern. Therefore, in this study, the performance of lysozyme (LYZ)/tracheal antimicrobial peptide (TAP)-based tissue-specific expression antimicrobial plasmids (TSEAP) have been evaluated in the treatment of mastitis in mice.
View Article and Find Full Text PDFHere we report results of a phase 1 multi-institutional, open-label, dose-escalation trial (NCT02744287) of BPX-601, an investigational autologous PSCA-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic pancreatic (mPDAC) or castration-resistant prostate cancer (mCRPC). Primary objectives were to evaluate safety and tolerability and determine the recommended phase 2 dose/schedule (RP2D). Secondary objectives included the assessment of efficacy and characterization of the pharmacokinetics of rimiducid.
View Article and Find Full Text PDFHealth Promot Int
December 2024
Faculty of Health, Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, Victoria, 3320, Australia.
Public health researchers have investigated how youth are exposed to and influenced by traditional forms of commercial marketing from health-harming industries. Limited research has investigated youth opinions about the broader marketing and public relations strategies of these industries. This study aimed to understand youth perceptions of the impact and influence of a range of marketing and public relations strategies used by health harming industries.
View Article and Find Full Text PDFAm J Clin Dermatol
November 2024
Institute of Allergology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 27, 12203, Berlin, Germany.
Urticarial vasculitis (UV) is a rare and difficult-to-treat, small-vessel leukocytoclastic vasculitis presenting with recurrent long-lasting wheals. So far, no guidelines and treatment algorithms exist that could help clinicians with the management of UV. In this review, we describe evidence on systemic treatments used for UV and propose a clinical decision-making algorithm for UV management based on the Urticarial Vasculitis Activity Score assessed for 7 days (UVAS7).
View Article and Find Full Text PDFChempluschem
October 2024
College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Long-chain bio-based polyamide has shown promising development prospects due to its excellent properties and green renewable characteristics; however, synthesizing inherently flame-retardant long-chain bio-based polyamide remains a big challenge due to the lack of effective knowledge of the key polymerization process. Herein, intrinsicly flame-retardant long-chain bio-based polyamide 512 (PA512) was synthesized in the presence of a reactive flame retardant with high thermal stability and good water solubility. The reaction conditions and existing problems in each stage of the copolymerization system have been clarified and optimized.
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