ERα in the Control of Mitochondrial Function and Metabolic Health.

Trends Mol Med

David Geffen School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, University of California, Los Angeles, CA 90095, USA.

Published: January 2021

Decrements in metabolic health elevate disease risk, including type 2 diabetes, heart disease, and certain cancers. Thus, treatment strategies to combat metabolic dysfunction are needed. Reduced ESR1 (estrogen receptor, ERα) expression is observed in muscle from women, men, and animals presenting clinical features of the metabolic syndrome. Human studies of natural expression of ESR1 in metabolic tissues show that muscle expression of ESR1 is positively correlated with markers of metabolic health, including insulin sensitivity. Herein, we highlight the important impact of ERα on mitochondrial form and function and present how these actions of the receptor govern metabolic homeostasis. Studies identifying ERα-regulated pathways for disease prevention will lay the foundation for the design of novel therapeutics to improve the health of women while limiting secondary complications that have plagued traditional hormone replacement interventions.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2020.09.006DOI Listing

Publication Analysis

Top Keywords

metabolic health
12
expression esr1
8
metabolic
7
erα control
4
control mitochondrial
4
mitochondrial function
4
function metabolic
4
health
4
health decrements
4
decrements metabolic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!