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| http://dx.doi.org/10.1016/j.jaci.2020.09.004 | DOI Listing |
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Efficacy of Donepezil for Fatigue and Psychological Symptoms in Post-COVID-19 Condition: Study Protocol for a Multicenter Randomized, Placebo-controlled, Double-blind Trial.
Ann Clin Epidemiol
October 2024
Department of Emergency and Critical Care Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
Background: Approximately 30% of coronavirus disease 2019 COVID-19 patients develop fatigue and psychological symptoms. We previously demonstrated the efficacy of donepezil, an acetylcholinesterase inhibitor that is widely used to treat dementia, in basic research.
Methods: This is a multicenter, double-blind, randomized, controlled, phase II clinical trial in which 120 patients with COVID-19 will be randomized in a 1:1 ratio to a donepezil or placebo group.
The relationship between parental smartphone dependence and elementary students' internet addiction during the COVID-19 lockdown in China: the mediating role of parent-child conflict and the moderating role of parental roles.
Front Psychol
December 2024
Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China.
During the COVID-19 lockdown in China, the shift of family members' work and study to online platforms accelerated internet proliferation and led to a growing prominence of internet addiction among younger age groups, posing a threat to individual and societal health development. Previous research has primarily focused on upper-grade elementary students, with relatively less attention given to younger age groups, resulting in insufficient representativeness of the elementary student samples. Additionally, research exploring how parental addictive behaviors are associated with the mechanisms of internet addiction among elementary students has been limited, which affects the development of scientifically based and effective intervention measures for addressing internet addiction in this population.
View Article and Find Full Text PDFCOVID-19 Pneumonia Diagnosed by Bronchoalveolar Lavage Fluid, With CD4 T-cell Depletion Contributing to Prolonged Infection: Two Case Reports.
Cureus
November 2024
Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, JPN.
Article Synopsis
- Patients treated with CD20 antibodies face a higher risk of severe COVID-19 infections, even if they test negative in nasal swabs.
- Bronchoalveolar lavage is crucial for accurate diagnosis of COVID-19 pneumonia in these patients, especially when CT scans show signs of viral pneumonia.
- CD4 T-cell depletion and low humoral immune responses due to treatments like bendamustine may contribute to ongoing COVID-19 issues, despite the presence of neutralizing antibodies.
The prevalence of in children in Shandong, China before, during, and after COVID-19.
Front Pediatr
December 2024
Department of Clinical Laboratory, Shandong Provincial Third Hospital, Shandong University, Jinan, Shandong, China.
Background: The multifaceted non-pharmaceutical interventions after the outbreak of the COVID-19 pandemic not only limited the spread of SARS-CoV2 but also had an impact on the prevalence of other pathogens.
Methods: In this work, we retrospectively analyzed the epidemiological characteristics of (MP) in children before and after the COVID-19 pandemic in Shandong, China. From 2019-2023, there were 29,558 visits of pediatric patients (1 month to 15 years old) with respiratory tract infection (RTI) symptoms at a tertiary hospital in Shandong Province, 10,039 of which were positive for MP according to a passive agglutination assay of the serum IgM antibodies.
Real-World Effectiveness of Bebtelovimab Versus Nirmatrelvir/Ritonavir in Outpatients with COVID-19.
Pulm Ther
December 2024
Eli Lilly and Company, Indianapolis, IN, USA.
Introduction: This real-world study assessed the effectiveness of bebtelovimab (BEB) versus nirmatrelvir/ritonavir (NR) among outpatients with COVID-19 during the Omicron variant era.
Methods: We conducted a cohort study evaluating patients treated with BEB or NR from February to August 2022 (study period). Follow-up began the day after treatment and continued for 30 days.
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