Ciguatera is a food intoxication caused by the consumption of primarily coral fish; these species exist in large numbers in the seas that surround the Colombian territory. The underreported diagnosis of this clinical entity has been widely highlighted due to multiple factors, such as, among others, ignorance by the primary care practitioner consulted for this condition as well as clinical similarity to secondary gastroenteric symptoms and common food poisonings of bacterial, parasitic or viral etiology. Eventually, it was found that people affected by ciguatoxins had trips to coastal areas hours before the onset of symptoms. Thanks to multiple studies over the years, it has been possible to identify the relation between toxigenic dinoflagellates and seagrasses, as well as its incorporation into the food chain, starting by fish primarily inhabiting reef ecosystems and culminating in the intake of these by humans. Identifying the epidemiological link, its cardinal symptoms and affected systems, such as gastrointestinal, the peripheral nervous system and, fortunately with a low frequency, the cardiovascular system, leads to a purely clinical diagnostic impression without necessitating further complementary studies; in addition, what would also help fight ciguatera poisoning is performing an adequate treatment of the symptoms right from the start, without underestimating or overlooking any associated complications.
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http://dx.doi.org/10.3390/md18100504 | DOI Listing |
J Org Chem
December 2024
Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
A highly convergent and scalable second-generation synthesis of the fully functionalized HIJKLMN-ring segment of Caribbean ciguatoxin C-CTX-1, the primary toxin responsible for ciguatera fish poisoning in the Caribbean Sea and the Northeast Atlantic regions, has been accomplished. Key aspects of the synthetic approach include the efficient syntheses of the HI- and KLM-ring fragments on gram scales, a convergent fragment coupling toward the HIJKLM-ring skeleton based on the Suzuki-Miyaura coupling strategy, and optimized iron hydride-catalyzed hydrogen atom transfer-mediated olefin coupling conditions for constructing the N-ring.
View Article and Find Full Text PDFAnal Chem
December 2024
IRTA, Marine and Continental Waters, Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.
Cell-based biosensors (CBBs) for the detection of marine neurotoxins such as ciguatoxins (CTXs) are of high interest due to the composite toxicological response they can provide and the low limits of quantification (LOQs) they can achieve with the use of sensitive neural cells. However, the development and validation of CBBs are challenging due to the use of living material and the need for appropriate signal transduction strategies. In this work, Neuro-2a cells have been immobilized on thin-film gold electrodes, and their viability after exposure to CTX1B has been evaluated with light optical microscopy as well as cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using methylene blue (MB) as a redox indicator.
View Article and Find Full Text PDFMar Drugs
November 2024
Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Harmful Algae
November 2024
Centre for Sustainable Tropical Fisheries and Aquaculture, James Cook University, Townsville 4811, Qld, Australia.
Shokuhin Eiseigaku Zasshi
October 2024
Faculty of Science, University of the Ryukyus.
Ciguatera fish poisoning (CFP), known as a seafood-borne disease, is caused by consumption of fish contaminated with ciguatoxins in tropical and subtropical sea. The ciguatera fishes, Variola louti, Lutjanus monostigma and L. bohar have an absolute majority in the Ryukyu Archipelago, southwestern Japan.
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