Acute Kidney Injury (AKI) is a common complication after surgery. Recognition of patients at risk of AKI at an earlier stage is a priority for researchers and health care providers. The objective of this study is to develop machine learning prediction models of acute kidney injury (AKI) in patients who undergo surgery. The dataset used in this study consists of in-hospital patients' data of five different cohorts coming from different major procedure types. This data was collected from the SunRiseClinical Manager (SCM) electronic medical records system that is used in the Calgary Zone, Alberta, Canada from 2008 to 2015 where the patients are >=18 years of age. Five classifiers were experimented with: support vector machine, random forest, logistic regression, k-nearest neighbors, and adaptive boosting. The area under the receiver operating characteristics curve (AUROC) ranged between 0.62-0.84 and sensitivity and specificity ranged between 0.81-0.83 and 0.43-0.85, respectively. Predictions from these models can facilitate early intervention in AKI treatment.
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http://dx.doi.org/10.1109/EMBC44109.2020.9175448 | DOI Listing |
J Med Internet Res
January 2025
Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, China.
Background: Acute kidney injury (AKI) is a common complication in hospitalized older patients, associated with increased morbidity, mortality, and health care costs. Major adverse kidney events within 30 days (MAKE30), a composite of death, new renal replacement therapy, or persistent renal dysfunction, has been recommended as a patient-centered endpoint for clinical trials involving AKI.
Objective: This study aimed to develop and validate a machine learning-based model to predict MAKE30 in hospitalized older patients with AKI.
PLoS One
January 2025
Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Müunster, Müunster, Germany.
Objective: Acute kidney injury (AKI) is a frequent complication in critically ill patients, affecting up to 50% of patients in the intensive care units. The lack of standardized and open-source tools for applying the Kidney Disease Improving Global Outcomes (KDIGO) criteria to time series, requires researchers to implement classification algorithms of their own which is resource intensive and might impact study quality by introducing different interpretations of edge cases. This project introduces pyAKI, an open-source pipeline addressing this gap by providing a comprehensive solution for consistent KDIGO criteria implementation.
View Article and Find Full Text PDFIndian J Pediatr
January 2025
Department of Internal Medicine, Yanbian University Hospital, Yanji, Jilin, 133002, China.
Dalton Trans
January 2025
Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt.
The photo-induced CO-releasing properties of the dark-stable complex [RuCl(CO)L] (L = 2-(pyridin-2-yl)quinoxaline) were investigated under 468 nm light exposure in the presence and absence of biomolecules such as histidine, calf thymus DNA and hen egg white lysozyme. The CO release kinetics were consistent regardless of the presence of these biomolecules, suggesting that they did not influence the CO release mechanism. The quinoxaline ligand demonstrated exceptional cytotoxicity against human acute monocytic leukemia cells (THP-1), with evidence of potential DNA damage ascertained by comet assay, while it remained non-toxic to normal kidney epithelial cells derived from African green monkey (Vero) cell lines.
View Article and Find Full Text PDFAdv Clin Exp Med
January 2025
School of Medicine, Hunan Polytechnic College of Environment and Biology, Hengyang, China.
Only a few studies have examined the effects of coronavirus disease 2019 (COVID-19) and influenza on clinical outcomes in pediatric patients. Furthermore, no meta-analysis has assessed the impact of these diseases on adverse outcomes. This study aims to compare the clinical outcomes of COVID-19 and influenza in pediatric patients.
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