The design of effective rehabilitation protocols relies on the ability to accurately assess the physical condition and the rehabilitative needs of the patient. Monitoring muscle fatigue can increase the usability of rehabilitative and restorative devices as it helps avoiding premature tiring and injury of patients whose resistance is already compromised. In this study, we collected EMG and accelerometer data from one healthy subject during a 30-minute walk on treadmill to determine the variations of muscle activation, and gait acceleration patterns, which, however subtle, could be interpreted as early indicators of muscle fatigue. Results show an increasing Tibialis Anterior (TA) and decreasing Soleus (SOL) and Gastrocnemius (GASL, GASM) activation towards the end of the task as compared to the beginning, as well as increasing acceleration peaks during the middle swing phase. By following the approach outlined here we can assess the efficiency and reduction of metabolic cost achieved by an exoskeleton. Furthermore, muscle fatigue may be linked to the efficacy of gait rehabilitation, where decreased muscle fatigue across sessions possibly indicates longer retention of benefits after training and increased walking capacity. This methodology can be used to benchmark novel exoskeletons, monitor fatigue to avoid premature tiring of patients, and optimize rehabilitation therapies.
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http://dx.doi.org/10.1109/EMBC44109.2020.9175315 | DOI Listing |
Heliyon
January 2025
Institute of Biomedicine of Málaga (IBIMA), 29010, Málaga, Spain.
Background: Chronic kidney disease is a global problem characterized by a progressive decrease in kidney function with associated symptoms. A better understanding of these symptoms could lead to the development of personalized strategies.
Objective: This systematic review aims to describe the clusters of symptoms in kidney failure and categorize them according to their time of onset and how disabling they are for patients.
PLoS One
January 2025
Academic Partnership Unit, Leeds Trinity University, Leeds, United Kingdom.
The fast-bowling action demands repetitive high-intensity whole body movements, imposing complex physical and perceptual demands on players that vary significantly throughout the season. This study aimed to assess and establish practical methods and metrics for quantifying fatigue after four simulated fast bowling spells. Eleven senior club male fast bowlers (age 27.
View Article and Find Full Text PDFJCEM Case Rep
February 2025
Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) is rare and may progress rapidly, making treatment very challenging. We report a 27-year-old woman with metastatic neuroendocrine tumor (NET) who presented with sudden onset and rapidly progressing fatigue, muscle weakness, and weight gain. Laboratory findings confirmed severe EAS with new onset hypocalcemia, hypokalemia, and hyperglycemia.
View Article and Find Full Text PDFFront Hum Neurosci
January 2025
Institute of Sport Sciences, Department of Human Motor Behavior, Academy of Physical Education, Katowice, Poland.
We investigated the effects of static and dynamic fatigue on motor synergies, focusing on their hierarchical control. Specifically, we examined whether changes in fatigue influence the central nervous system's ability to preserve movement stability. In addition to exploring the direct impact of fatigue on motor synergies, we also analyzed its effects at two distinct levels of hierarchical control, aiming to elucidate the mechanisms by which fatigue alters motor coordination and stability.
View Article and Find Full Text PDFCurr Mol Med
January 2025
Department of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence, FI, Italy.
Background: Growth Differentiation Factor 15 (GDF15) has been described as influencing skeletal physiology. Nevertheless, no systematic appraisal of the effect of GDF15 on skeletal muscle tissues has been developed to the present day.
Objective: The aim of the present work was to review the evidence on the topic.
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