A Pilot Study on Scatterer Density Classification of Ultrasound Images Using Deep Neural Networks.

Quantitative ultrasound estimates different intrinsic tissue properties, which can be used for tissue characterization. Among different tissue properties, the effective number of scatterers per resolution cell is an important parameter, which can be estimated by the echo envelope. Assuming the signal is stationary and coherent, if the number of scatterers per resolution cell is above approximately 10, envelope signal is considered to be fully developed speckle (FDS) and otherwise they are from low scatterer number density (LSND). Two statistical parameters named R and S are often calculated from envelope intensity to classify FDS from LSND. The main problem is that limited data from small patches often renders this classification inaccurate. Herein, we propose two techniques based on neural networks to estimate the effective number of scatterers. The first network is a multi-layer perceptron (MLP) that uses the hand-crafted features of R and S for classification. The second network is a convolutional neural network (CNN) that does not need hand-crafted features and instead utilizes spectrum and the envelope intensity directly. We show that the proposed MLP works very well for large patches wherein a reliable estimation of R and S can be made. However, its classification becomes inaccurate for small patches, where the proposed CNN provides accurate classifications.