Subretinal stimulators help restoring vision to blind people, suffering from degenerative eye diseases. This work aims to reduce patient's efforts to continuously tune his device, by implementing a physiological ambient illumination adaptation system. The parameters of the adaptation to changing illumination conditions are highly customizable, to best fit individual patients requirements.
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http://dx.doi.org/10.1109/EMBC44109.2020.9175818 | DOI Listing |
Background: Agitation, affecting 30% of people living with dementia (PLwD), presents with heterogeneity, diverse triggers, and variable responses to interventions. Subtype identification particularly in real-world settings, thus, holds promise for more tailored care.
Method: We used longitudinal, in-home monitoring data from 61 PLwD from the Minder study.
Background And Aims: This study investigates the global impact of ambient ultraviolet radiation (UVR) on dementia incidence, addressing its controversial association with dementia risk. UVR, through both vitamin D-dependent and independent mechanisms, influences physiological processes essential for brain health, such as reducing neuroinflammation, improving sleep regulation, and enhancing neuroplasticity. This study aims to clarify the relationship between UVR and dementia incidence and evaluate its role in public health strategies for dementia prevention.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Human Molecular Genetics and Biochemistry, Faculty of Health & Medical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Ataxia-telangiectasia (A-T) is a pleiotropic genome instability syndrome resulting from the loss of the homeostatic protein kinase ATM. The complex phenotype of A-T includes progressive cerebellar degeneration, immunodeficiency, gonadal atrophy, interstitial lung disease, cancer predisposition, endocrine abnormalities, chromosomal instability, radiosensitivity, and segmental premature aging. Cultured skin fibroblasts from A-T patients exhibit premature senescence, highlighting the association between genome instability, cellular senescence, and aging.
View Article and Find Full Text PDFBioengineering (Basel)
December 2024
Biomedical Sensors & Systems Lab, University of Memphis, Memphis, TN 38152, USA.
A battery-operated biomedical wearable device gradually assists in clinical tasks to monitor patients' health states regarding early diagnosis and detection. This paper presents the development of a self-powered portable electronic module by integrating an onboard energy-harvesting facility for electrocardiogram (ECG) signal processing and personalized health monitoring. The developed electronic module provides a customizable approach to power the device using a lithium-ion battery, a series of silicon photodiode arrays, and a solar panel.
View Article and Find Full Text PDFLab Chip
January 2025
Nanobioelectronics Laboratory (NBEL), Department of Biomedical Engineering, Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, 8410501 Beer Sheva, Israel.
Dissolved oxygen is crucial for metabolism, growth, and other complex physiological and pathological processes; however, standard physiological models (such as organ-on-chip systems) often use ambient oxygen levels, which do not reflect the lower levels that are typically found . Additionally, the local generation of reactive oxygen species (ROS; a key factor in physiological systems) is often overlooked in biology-mimicking models. Here, we present a microfluidic system that integrates electrochemical dissolved oxygen sensors with lab-on-a-chip technology to monitor the physiological oxygen concentrations and generate hydrogen peroxide (HO; a specific ROS).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!