Despite the enormous potential applications, non-invasive recordings have not yet made enough satisfaction for fetal disease detection. This is mainly due to the fetal ECG signal is contaminated by the maternal electrocardiograph (ECG) interference, muscle contractions, and motion artifacts. In this paper, we propose a joint multiple subspace-based blind source separation (BSS) approach to extract the fetal heart rate (HR), so that it could greatly reduce the effect of maternal ECG and motion artifacts. The approach relies on the estimation of the coefficient matrix formulated as the tensor decomposition in terms of multiple datasets. Since the objective function takes the coupling information from the stacking of the covariance matrix for multiple datasets into account, estimating the coefficient matrices is fulfilled not only on dependence across multiple datasets, but also can combine the extracted components across four different datasets. Numerical results demonstrate that the proposed method can achieve a high extracted HR accuracy for each dataset, when compared to some conventional methods.
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http://dx.doi.org/10.1109/EMBC44109.2020.9175307 | DOI Listing |
Front Biosci (Landmark Ed)
December 2024
Graduate School of Information Science and Technology, Osaka University, 565-0871 Suita, Osaka, Japan.
Background: Fusion genes are important biomarkers in cancer research because their expression can produce abnormal proteins with oncogenic properties. Long-read RNA sequencing (long-read RNA-seq), which can sequence full-length mRNA transcripts, facilitates the detection of such fusion genes. Several tools have been proposed for detecting fusion genes in long-read RNA-seq datasets derived from cancer cells.
View Article and Find Full Text PDFJ Inflamm Res
December 2024
Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, People's Republic of China.
Objective: A comprehensive bioinformatics analysis was conducted to investigate potential new diagnostic biomarkers and immune infiltration characteristics associated with tubulointerstitial injury in lupus nephritis (LN), and to examine possible correlations between key genes and infiltrating immune cells.
Methods: The GSE32591, GSE113342, and GSE200306 datasets were downloaded from the Gene Expression Omnibus database and differentially expressed genes (DEGs) were identified in the pooled dataset. Support vector machine-recursive feature elimination analysis and the least absolute shrinkage and selection operator regression model were used to screen for possible markers, and the compositional patterns of the 22 types of immune cell fractions in LN were determined using CIBERSORT.
J Inflamm Res
December 2024
Department of Dermatology, China-Japan Friendship Hospital, National Center for Integrative Medicine, Beijing, 100029, People's Republic of China.
Background: Psoriasis represents a persistent, immune-driven inflammatory condition affecting the skin, characterized by a lack of well-established biologic treatments without adverse events. Consequently, the identification of novel targets and therapeutic agents remains a pressing priority in the field of psoriasis research.
Methods: We collected single-cell RNA sequencing (scRNA-seq) datasets and inferred T cell differentiation trajectories through pseudotime analysis.
JAMIA Open
February 2025
Hasso Plattner Institute for Digital Engineering, University of Potsdam, Potsdam 14482, Germany.
Objective: To improve performance of medical entity normalization across many languages, especially when fewer language resources are available compared to English.
Materials And Methods: We propose xMEN, a modular system for cross-lingual (x) medical entity normalization (MEN), accommodating both low- and high-resource scenarios. To account for the scarcity of aliases for many target languages and terminologies, we leverage multilingual aliases via cross-lingual candidate generation.
Front Oncol
December 2024
Department of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, China.
Background: Prostate cancer (PCa) ranks as the second leading cause of cancer-related mortality among men. Long non-coding RNAs (lncRNAs) are known to play a regulatory role in the development of various human cancers. LncRNA MAFG-divergent transcript (MAFG-DT) was reported to play a crucial role in tumor progression of multiple human cancers, such as pancreatic cancer, colorectal cancer, bladder cancer, and gastric cancer.
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