AI Article Synopsis
- The study aimed to evaluate how well the sirolimus-eluting ultrathin-strut drug-eluting stent (Orsiro) performs in real-world clinical settings among patients undergoing coronary procedures in Sweden.
- After analyzing data from over 74,000 patients, the results showed low rates of stent thrombosis and restenosis in both the Orsiro and other newer-generation drug-eluting stents (n-DES), with Orsiro linked to a lower need for revascularization procedures.
- Overall, the findings suggest that the Orsiro stent has positive clinical outcomes, with comparable risks of mortality and heart attacks to other stents used in the study.
Article Abstract
Aims: The aim of this study was to assess the real-world clinical performance of a sirolimus-eluting ultrathin-strut drug-eluting stent (DES) (Orsiro) in a large nationwide cohort of patients undergoing percutaneous coronary intervention (PCI).
Methods And Results: From the Swedish Coronary Angiography and Angioplasty Registry, the two-year outcomes of 4,561 patients implanted with Orsiro (Orsiro group) and 69,570 receiving other newer-generation DES (n-DES group) were analysed. The rate of definite stent thrombosis was low in both groups (0.67% and 0.83% for Orsiro and n-DES, respectively; adjusted hazard ratio [HR] 0.90, 95% confidence interval [CI]: 0.55-1.46, p-value 0.66). Restenosis was also infrequent (1.5% vs 2.0% with Orsiro and n-DES, adjusted HR 0.81, 95% CI: 0.63-1.03, p-value=0.09). The risk of target lesion revascularisation by PCI was lower in the Orsiro group (1.6% vs 2.3%, adjusted HR 0.75, 95% CI: 0.60-0.94, p-value=0.013). All-cause mortality and myocardial infarction did not show a statistically significant difference between the two groups (mortality of 7.5% in both groups, adjusted HR 0.99, 95% CI: 0.72-1.35, p-value=0.94; 6.0% vs 5.2% for myocardial infarction, adjusted HR 1.19, 95% CI: 1.00-1.43, p-value=0.06).
Conclusions: In a nationwide scenario, the use of a sirolimus-eluting ultrathin-strut DES portended favourable clinical outcomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724977 | PMC |
| http://dx.doi.org/10.4244/EIJ-D-20-00429 | DOI Listing |
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