One new piperazinedione derivative, nigerpiperazine A (), along with six known compounds () were isolated from the fungus JX-5 from mangrove . Nigerpiperazine A () was elucidated by spectroscopic analyses and C NMR chemical shift calculations, compounds and were determined by X-ray and the CD spectra. The absolute configuration of was identified by X-ray for the first time. Compounds and showed inhibitory activities against Hubner with the IC values of 200 and 100 µg/mL, respectively.
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