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A new cytotoxic indole alkaloid from the fungus TY12. | LitMetric

A new cytotoxic indole alkaloid from the fungus TY12.

Nat Prod Res

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, P.R. China.

Published: May 2022

A new dimeric monoterpene indole alkaloid polonidine A (), along with five known compounds, cyclopenol (), verrucosidin (), fructigenine A (), 3-O-methylviridicatin () and aurantiomides C (), were isolated from TY12. Their structures were established on the basis of extensive spectroscopic analyses. Compound exhibited moderate cytotoxic activities and moderate antibacterial activity against with MIC of 4.0 μg/mL.

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Source
http://dx.doi.org/10.1080/14786419.2020.1828406DOI Listing

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