AI Article Synopsis
- Subjective cognitive decline (SCD) might indicate early signs of Alzheimer's disease, but there's a lack of classification methods for it in community studies.
- A study involving 1,115 older adults found that self-perceived cognitive functioning is linked to the development of amnestic mild cognitive impairment (aMCI), even when accounting for various demographic and cognitive factors.
- The researchers proposed a method for classifying SCD and highlighted its significance for understanding cognitive aging.
Article Abstract
Introduction: Subjective cognitive decline (SCD) may be an early symptomatic manifestation of Alzheimer's disease, though published research largely neglects how to classify SCD in community-based studies.
Methods: In neuropsychologically intact Einstein Aging Study participants (n = 1115; mean age = 78; 63% female; 30% non-White), we used Cox models to examine the association between self-perceived cognitive functioning at baseline (using three different approaches) and incident amnestic mild cognitive impairment (aMCI) with covariates of age, sex, education, race/ethnicity, general (objective) cognition, depressive symptoms, and four other SCD-related features.
Results: After a median of 3 years, 198 participants developed aMCI. In models that included all the variables, self-perceived cognitive functioning was consistently associated with incident aMCI as were age, general cognition, and perceived control; apolipoprotein E (APOE) ε4 allele status was significant in one model. We set cut points that optimized the diagnostic accuracy of SCD at various time frames.
Discussion: We provide an approach to SCD classification and discuss implications for cognitive aging studies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521594 | PMC |
| http://dx.doi.org/10.1002/dad2.12103 | DOI Listing |
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