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| http://dx.doi.org/10.1016/j.patol.2020.09.001 | DOI Listing |
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EWSR1 translocation in primary hyalinising clear cell carcinoma of the thymus.
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Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.
Aims: In thymic carcinomas, focal clear cell change is a frequent finding. In addition to a prominent, diffuse clear cell morphology, some of these carcinomas show an exuberant hyalinised extracellular matrix, and therefore probably represent a separate entity. However, a characteristic genomic alteration remains elusive.
View Article and Find Full Text PDFInterobserver Variability in the Histopathologic Assessment of Extrathyroidal Extension of Well Differentiated Thyroid Carcinoma Supports the New American Joint Committee on Cancer Eighth Edition Criteria for Tumor Staging.
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12 Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida.
Extrathyroidal extension (ETE) by papillary and follicular thyroid carcinoma can be associated with increased risk of tumor recurrence and mortality. In the seventh edition of its Cancer Staging Manual, the American Joint Committee on Cancer (AJCC) defined minimal ETE as the involvement of skeletal muscle (i.e.
View Article and Find Full Text PDFSolid Papillary Breast Carcinomas Resembling the Tall Cell Variant of Papillary Thyroid Neoplasms: A Unique Invasive Tumor With Indolent Behavior.
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*Department of Biomedical and Neuromotor Sciences, Section of Pathology "M. Malpighi," University of Bologna, Bologna ∥Department of Pathology, CDI, Milano, Italy †Pathology Unit, Laboratories Dr. Macedo Dias, Porto, Portugal ‡Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary §Department of Histopathology, Nottingham City Hospital, Nottingham, United Kingdom.
Thirteen cases of invasive solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (BPTC) are reported here. Some cases had long-term follow-up. BPTC is a special type of primary breast neoplasm showing a triple-negative profile but low aggressive potential.
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Unit of Diagnostic Haematopathology, European Institute of Oncology, Milan, Italy.
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumors with variable clinical, morphologic, and phenotypic characteristics. Transcriptome analysis was performed on multiple FDC sarcomas and compared with other mesenchymal tumors, microdissected Castleman FDCs, and normal fibroblasts. Using unsupervised analysis, FDC sarcomas clustered with microdissected FDCs, distinct from other mesenchymal tumors and fibroblasts.
View Article and Find Full Text PDFNuclear Bubbles (Nuclear Pseudo-Pseudoinclusions): A Pitfall in the Interpretation of Microscopic Sections From the Thyroid and Other Human Organs.
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*Pathology Unit, Department of Molecular and Translational Medicine University of Brescia Spedali Civili di Brescia †International Center for Oncologic Pahology Consultations, Centro Diagnostico Italiano, Milano, Italy.
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