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| http://dx.doi.org/10.1002/ejhf.2019 | DOI Listing |
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State of precision medicine for heart failure with preserved ejection fraction in a new therapeutic age.
ESC Heart Fail
January 2025
Faculty of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, Queensland, Australia.
Heart failure with preserved ejection fraction (HFpEF) is defined by heart failure (HF) with a left ventricular ejection fraction (LVEF) of at least 50%. HFpEF has a complex and heterogeneous pathophysiology with multiple co-morbidities contributing to its presentation. Establishing the diagnosis of HFpEF can be challenging.
View Article and Find Full Text PDFThe Oxygen Cascade According to HFpEF Likelihood: A Focus on Sex Differences.
JACC Adv
July 2024
Department of Cardiology, JESSA Hospital, Hasselt, Belgium.
Background: Women are at greater risk for heart failure with preserved ejection fraction (HFpEF).
Objectives: The aim of the study was to compare sex differences in the pathophysiology of exertional breathlessness in patients with high vs low HFpEF likelihood.
Methods: This cohort study evaluated consecutive patients (n = 1,936) with unexplained dyspnea using cardiopulmonary exercise testing and simultaneous echocardiography and quantified peak oxygen uptake (peak VO) and its determinants.
HFPEF and HFA-PEFF scores performance and the additional value of cardiac structure and function in patients with atrial fibrillation.
Int J Cardiol
October 2024
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical specialties, Radiological sciences and Public Health, University of Brescia, Brescia, Italy. Electronic address:
Article Synopsis
- This study investigates the effectiveness of HFPEF and HFA-PEFF scores in diagnosing heart failure with preserved ejection fraction (HFpEF) in patients with atrial fibrillation (AF), with a focus on their association with invasive left atrial pressure (LAP).
- Researchers found that while higher scores indicated worse cardiac function, they did not show a significant link to elevated mean LAP.
- Adding the measurement of left atrial indexed minimal volume (LAVi min) to these scores improved their accuracy in detecting elevated filling pressure in the studied patients.
Uncovering Unrecognized Heart Failure With Preserved Ejection Fraction Among Individuals With Obesity and Dyspnea.
Circ Heart Fail
May 2024
Division of Cardiology (L.B.K., E.E.L., J.K.W., J.K.P., J.M.R., R.E.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
Background: Although heart failure with preserved ejection fraction (HFpEF) has become the predominant heart failure subtype, it remains clinically under-recognized. HFpEF diagnosis is particularly challenging in the setting of obesity given the limitations of natriuretic peptides and resting echocardiography. We examined invasive and noninvasive HFpEF diagnostic criteria among individuals with obesity and dyspnea without known cardiovascular disease to determine the prevalence of hemodynamic HFpEF in the community.
View Article and Find Full Text PDF[Applicability of HFPEF and HFA-PEFF Scores in Chinese Patients Suffering From Heart Failure With Preserved Ejection Fraction and Heart Failure With Preserved Ejection Fraction Complicated With Atrial Fibrillation].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
April 2024
2 Department of Geriatric Cardiology,Gansu Provincial Clinical Research Center for Geriatric Medicine, The First Hospital of Lanzhou University,Lanzhou 730000,China.
Objective To analyze the diagnostic values of HFPEF and HFA-PEFF scores for heart failure with preserved ejection fraction (HFpEF) and HFpEF complicated with atrial fibrillation (HFpEF-AF) in Chinese patients and explore the related factors. Methods A cross-sectional study was conducted.A total of 835 consecutive HFpEF patients treated in the Department of Geriatric Cardiology,the First Hospital of Lanzhou University from 2009 to 2020 were selected and assigned to a HFpEF-AF group (=267) and a HFpEF group (=568) according to the presence of AF or not.
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