AI Article Synopsis
- - Polysorbates, specifically Tween 60 and Tween 80, are commonly used to encapsulate essential oils like R-(+)-limonene (LMN) in microemulsions, which were examined for their structural and antimicrobial properties.
- - The study utilized pseudoternary phase diagrams to create and characterize these microemulsions, revealing that they maintained spherical shapes and showed a decrease in size during dilution, while also demonstrating similar phase transitions for the two polysorbate types.
- - The microemulsions displayed enhanced antimicrobial activity against bacteria such as Staphylococcus aureus, E. coli, and Pseudomonas aeruginosa, with Tween 60 proving more effective against S. aure
Article Abstract
Polysorbates (Tweens) are one of the most used excipients for essential oils encapsulation. In this work, the polysorbate based microemulsions (PMEs) for R-(+)-limonene (LMN) encapsulation were investigated for the structural and antimicrobial properties. PMEs were constructed using the pseudoternary phase diagrams, and then characterized for electrical conductivity, rheology, size distribution and particle geometry. Conductivity and rheological measurement results showed that Tween 80 and Tween 60 based microemulsions have identical phase transitions. Dynamic light scattering demonstrated that hydrodynamic diameters of oil-in-water microemulsions decreased from 30 nm to 25 nm during the dilution, while small-angle X-ray scattering indicated that their spherical geometries were maintained. PMEs exhibited enhanced antimicrobial efficiencies in vitro against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Interestingly, when Tween 80 was replaced by Tween 60, PME was observed more effective against S. aureus. The two PMEs structural analogues exhibited different antimicrobial efficiencies corresponding to the bioactivity of polysorbates. In conclusion, PMEs can be considered as a desirable system for LMN encapsulation to enhance its solubility and antimicrobial efficiency. Furthermore, the difference in the antimicrobial efficiency suggested that the choice of emulsifiers should be concerned to improve further applications.
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| http://dx.doi.org/10.1016/j.ijpharm.2020.119939 | DOI Listing |
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