AI Article Synopsis
- The abscopal effect is when treatment (like radiation) helps tumors that aren't directly being treated, and it was noticed back in the 1950s.
- A 69-year-old woman with lung cancer had a surprising shrinkage of one tumor after she received radiation therapy for another nearby tumor.
- This report is the first to show the abscopal effect in this specific type of lung cancer, and scientists need to study more about how this happens and if combining radiation with other treatments can help even more.
Article Abstract
Background: The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role.
Case Presentation: We report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion.
Conclusions: To our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532944 | PMC |
| http://dx.doi.org/10.1186/s13256-020-02512-8 | DOI Listing |
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