Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment.

J Control Release

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA. Electronic address:

Published: January 2021

Clinically efficacious medication in anticancer therapy has been successfully designed with liposome-based nanomedicine. The liposomal formulation in cancer drug delivery can be facilitated with a functionalized peptide that mediates the specific drug delivery opportunities with increased drug penetrability, specific accumulation in the targeted site, and enhanced therapeutic efficacy. This review aims to focus on recent advances in peptide-functionalized liposomal formulation techniques in cancer diagnosis and treatment regarding recently published literature. It also will highlight different aspects of novel liposomal formulation techniques that incorporate surface functionalization with peptides for better anticancer effect and current challenges in peptide-functionalized liposomal drug formulation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082750PMC
http://dx.doi.org/10.1016/j.jconrel.2020.09.055DOI Listing

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