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Does Allostatic Load in 50-89-Year-Olds Predict the Development of Frailty? Evidence From a National Longitudinal Study Over 12 Years.
Stress Health
December 2024
Global Academy of Health and Human Performance, Cardiff Metropolitan University, Cardiff, UK.
Frailty is characterised by a loss of function across several domains but is not an inevitable aspect of ageing and can be reversed with intervention. Determining those who are more likely to become frail before physical deficits become manifest will allow earlier intervention. One promising indicator of the potential for frailty is allostatic load, a physiological status associated with prolonged stress that is, characterised by multisystem dysfunction.
View Article and Find Full Text PDFEarly-life glucocorticoids accelerate lymphocyte count senescence in roe deer.
Gen Comp Endocrinol
October 2024
Université de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, F-69622 Villeurbanne, France; Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile, France. Electronic address:
Immunosenescence corresponds to the progressive decline of immune functions with increasing age. Although it is critical to understand what modulates such a decline, the ecological and physiological drivers of immunosenescence remain poorly understood in the wild. Among them, the level of glucocorticoids (GCs) during early life are good candidates to modulate immunosenescence patterns because these hormones can have long-term consequences on individual physiology.
View Article and Find Full Text PDFThe feigned annoyance and frustration test to activate the sympathoadrenal medullary system.
Compr Psychoneuroendocrinol
May 2024
Loma Linda University School of Allied Health Professions Department of Physical Therapy, 24951 N. Circle Dr., A-620, Loma Linda, CA, 92350, USA.
When perceived as threatening, social interactions have been shown to trigger the sympathoadrenal medullary system as well as the hypothalamic-pituitary-adrenal axis resulting in a physiologic stress response. The allostatic load placed on human health and physiology in the context of acute and chronic stress can have profound health consequences. The purpose of this study was to develop a protocol for a lab-based stress stimulus using social-evaluative threat.
View Article and Find Full Text PDFA review of dairy food intake for improving health among black geriatrics in the US.
J Natl Med Assoc
April 2024
Baylor University Medical Center, Dallas, TX, United States.
The transition to older adulthood is generally marked by progressive declines in body composition, metabolism, cognitive function, and immunity. For socially disadvantaged geriatric populations such as Black Americans, this life stage may also include additional stressors, including dealing with discrimination, poor access to healthcare, and food insecurity. These types of chronic stressors are linked to a higher allostatic load, which is associated with accelerated biological aging, higher rates of adverse health outcomes, and an overall lower quality of life.
View Article and Find Full Text PDFRole of Gut Microbiota, Immune Imbalance, and Allostatic Load in the Occurrence and Development of Diabetic Kidney Disease.
J Diabetes Res
December 2023
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Diabetic kidney disease (DKD) is a prevailing complication arising from diabetes mellitus. Unfortunately, there are no trustworthy and efficacious treatment modalities currently available. In recent times, compelling evidence has emerged regarding the intricate correlation between the kidney and the gut microbiota, which is considered the largest immune organ within the human physique.
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