Oral submucous fibrosis (OSF) is a collagen deposition disorder that affects a patient's oral function and quality of life. It may also potentially transform into malignancy. This review summarizes the risk factors, pathogenic mechanisms, and treatments of OSF based on clinical and bio-molecular evidence. Betel nut chewing is a major risk factor that causes OSF in Asia. However, no direct evidence of arecoline-induced carcinogenesis has been found in animal models. Despite identification of numerous biomarkers of OSF lesions and conducting trials with different drug combinations, clinicians still adopt conservative treatments that primarily focus on relieving the symptoms of OSF. Treatments focus on reducing inflammation and improving mouth opening to improve a patient's quality of life. In conclusion, high-quality clinical studies are needed to aid clinicians in developing and applying molecular biomarkers as well as standard treatment guidelines.
Department of Oral & Maxillofacial Surgery, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha, 410000, China.
Oral submucous fibrosis (OSF) is a precancerous condition that poses substantial health risks. OSF is mainly caused by betel nut chewing behavior, but its pathogenesis is still unclear and there is no effective treatment strategy. The transformation of fibroblasts to myofibroblast is the key pathological change in the development of OSF.
Oral submucous fibrosis (OSF) is a precancerous lesion of the oral cavity. Areca nut consumption can cause OSF through sustained activation of buccal mucosal fibroblasts (BMFs). This study explored the effect of curcumin on arecoline-induced BMF activation and its mechanism of action.
Background: Lorry drivers work tirelessly behind the wheels, commuting from one place to another without regular and adequate food, rest and sleep. These people often have odd working hours, long work shifts with frequent changes to their work schedule. In addition, they work in unfavorable climate conditions and face variety of problems like traffic congestions, vehicle fumes, vibrations and poor conditions of roads.
Chewing tobacco use is a significant public health concern in India, especially linked to the rising rates of oral cancer among young adults.
A study involving 1,209 patients revealed a high prevalence of chewing tobacco, particularly among men aged 26-35, with many consuming it frequently throughout the day.
The study concluded that chewing tobacco is closely associated with oral mucosal lesions, highlighting the need for public health efforts to change cultural attitudes and enforce stricter regulations against tobacco use.
Aim: The aim of the present study was to compare the effectiveness of low-level laser therapy and intralesional injection in oral submucous fibrosis (OSMF) patients.
Materials And Methods: The present study comprised of 52 grade II OSMF patients aged between 20 and 60 years. A pretreatment assessment was done for each patients.
