With the current worldwide outbreak of COVID-19, developing rapid, effective, and convenient detection tools has become imperative [...].
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| http://dx.doi.org/10.3390/diagnostics10100774 | DOI Listing |
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Activation of P38 MAPK Signaling Cascade is Linked with Clinical Outcomes and Therapeutic Responses in Human Cancers.
Biochemistry (Mosc)
December 2024
Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Activation of the p38 mitogen-activated protein kinase (MAPK) pathways is vital in regulating cell growth, differentiation, apoptosis, and stress response, significantly affecting tumorigenesis and cancer progression. We developed a bioinformatic technique to construct an interactome network-based molecular pathways for genes of interest and quantify their activation levels using high-throughput gene expression data. This study is focused on the p38α, p38β, p38γ, and p38δ kinases, examining their activation levels (PALs) based on transcriptomic data and their associations with survival and drug responsiveness across various cancer types.
View Article and Find Full Text PDFRevisiting epigenetic regulation in cancer: Evolving trends and translational implications.
Int Rev Cell Mol Biol
January 2025
Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, India. Electronic address:
Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance.
View Article and Find Full Text PDFGrowth and differentiation factor 15: An emerging therapeutic target for brain diseases.
Biosci Trends
January 2025
Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Growth and differentiation factor 15 (GDF15), a member of the transforming growth factor-βsuperfamily, is considered a stress response factor and has garnered increasing attention in recent years due to its roles in neurological diseases. Although many studies have suggested that GDF15 expression is elevated in patients with neurodegenerative diseases (NDDs), glioma, and ischemic stroke, the effects of increased GDF15 expression and the potential underlying mechanisms remain unclear. Notably, many experimental studies have shown the multidimensional beneficial effects of GDF15 on NDDs, and GDF15 overexpression is able to rescue NDD-associated pathological changes and phenotypes.
View Article and Find Full Text PDFFrom light to insight: Functional near-infrared spectroscopy for unravelling cognitive impairment during task performance.
Biosci Trends
January 2025
Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cognitive impairment refers to the impairment of higher brain functions such as perception, thinking or memory that affects the individual's ability to perform daily or social activities. Studies have found that changes in neuronal activity during tasks in patients with cognitive impairment are closely related to changes in cerebral cortical hemodynamics. Functional near-infrared spectroscopy is an indirect method to measure neural activity based on changes in blood oxygen concentration in the cerebral cortex.
View Article and Find Full Text PDFOptimization of the acceleration of compression sensing in whole-heart contrast-free coronary magnetic resonance angiography.
J Cardiovasc Magn Reson
January 2025
Philips Healthcare, Beijing 100600, China.
Background: This study aims to identify optimal acceleration factors (AFs) for compressed sensing (CS) technology to enhance its clinical application for suspected coronary artery disease (CAD) in whole-heart non-contrast coronary magnetic resonance angiography (CMRA).
Methods: Two hundred and seventeen individuals with suspected CAD underwent whole-heart non-contrast CMRA on a 1.5-T CMR scanner with CS AFs of 2, 4, and 6 (CS2, CS4, and CS6).
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