Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although piglets were not susceptible to SARS-CoV-2 and lacked lesions or viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally (intramuscularly or intravenously).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7537152PMC
http://dx.doi.org/10.1111/tbed.13861DOI Listing

Publication Analysis

Top Keywords

susceptible sars-cov-2
8
pigs susceptible
4
sars-cov-2 infection
4
infection model
4
model viral
4
viral immunogenicity
4
immunogenicity studies
4
studies conventional
4
conventional piglets
4
piglets inoculated
4

Similar Publications

Background: SARS-CoV-2 and COVID-19 are still active in the population. Some patients remained PCR-positive for more than 4 weeks, called "persistently PCR-positive". Recent evidence suggests a link between the gut microbiota and susceptibility to COVID-19, although no studies have explored persistent PCR conditions.

View Article and Find Full Text PDF

[Viral-epigenetic hypothesis of Parkinson's disease etiopathogenesis.].

Adv Gerontol

January 2025

Bashkir State Medical University, 3 Lenin str., Ufa 450008, Russian Federation, e-mail:

Data accumulated in scientific literature indicate that Parkinson's disease develops after infections caused by SARS-CoV-2, West Nile, Coxsackie, St. Louis viruses, Japanese encephalitis B, hepatitis B and C, influenza A, HIV, herpes viruses, flaviviruses. Neuroinvasive West Nile viruses and HIV activate expression of alpha-synuclein.

View Article and Find Full Text PDF

Background: Patients with rheumatic diseases who receive long-term treatment with steroids, immunosuppressants, or biologics are more susceptible to infection with pathogens than the general population. In order to explore the differences in clinical features and prognosis of Corona Virus Disease 2019 (COVID-19) infection between patients with rheumatic diseases and the general population (family members), a retrospective investigative study was used to analyze the differences between the two populations.

Methods: The study was conducted in 13 Grade A Tertiary hospitals in China to investigate the clinical symptoms and prognostic factors of patients with rheumatic diseases who were infected with COVID-19 for the first time and their families.

View Article and Find Full Text PDF

Approximation of the infection-age-structured SIR model by the conventional SIR model of infectious disease epidemiology.

Front Epidemiol

December 2024

Biostatistics and Medical Biometry, Medical School OWL, Bielefeld University, Bielefeld, Germany.

During the SARS-CoV-2 pandemic, the effective reproduction number (R-eff) has frequently been used to describe the course of the pandemic. Analytical properties of R-eff are rarely studied. We analytically examine how and under which conditions the conventional susceptible-infected-removed (SIR) model (without infection age) serves as an approximation to the infection-age-structured SIR model.

View Article and Find Full Text PDF

In this article, a nonlinear fractional bi-susceptible [Formula: see text] model is developed to mathematically study the deadly Coronavirus disease (Covid-19), employing the Atangana-Baleanu derivative in Caputo sense (ABC). A more profound comprehension of the system's intricate dynamics using fractional-order derivative is explored as the primary focus of constructing this model. The fundamental properties such as positivity and boundedness, of an epidemic model have been proven, ensuring that the model accurately reflects the realistic behavior of disease spread within a population.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!