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Nonketotic hyperglycemia-induced hemichorea is a rare condition of type 2 diabetes. It is characterized by hyperglycemia with the symptom traced to the basal ganglion like hemichorea or hemiballism, with the hyperintensity within basal ganglion presented in computed tomography (CT) or hyper signal in T1-weighted magnetic resonance image (MRI). It was also confirmed with a relatively better prognosis in that the symptoms of these patients could be relieved after the alleviation of hyperglycemia.

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Article Synopsis
  • * A 70-year-old Hispanic man with a history of diabetes and other health issues presented with severe left-sided involuntary movements for three weeks due to hyperglycemia.
  • * The patient's symptoms improved after his blood sugar levels were normalized, emphasizing the importance of managing diabetes and recognizing NKH-CB early for effective treatment.
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Hyperglycemic Chorea.

AACE Clin Case Rep

February 2024

Division of Endocrinology, Department of Medicine, Montefiore Medical Center, Bronx, New York.

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Diabetic striatopathy, a rare hyperglycemia complication, is characterized by chorea/ballism and striatal anomalies on neuroimaging, usually managed with glycemic control and haloperidol. However, practical strategies for haloperidol-resistant cases are scarce. We describe a 76-year-old Japanese woman with diabetic striatopathy who initially presented with polydipsia, polyuria, and lower-extremity weakness.

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Non-ketotic hyperglycemic hemichorea (NHH) denotes acute hemichorea or hemiballism in patients with poorly controlled diabetes with striatal abnormalities seen on brain MRI. Here, we describe a case with diabetes mellitus and primary hypoparathyroidism who developed NHH with bilateral chorea due to the abrupt stopping of her diabetic regimen. She presented with subacute and progressive bilateral asymmetric chorea.

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