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Regulator of Lipid Metabolism NHR-49 Mediates Pathogen Avoidance through Precise Control of Neuronal Activity.
Cells
June 2024
Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.
Precise control of neuronal activity is crucial for the proper functioning of neurons. How lipid homeostasis contributes to neuronal activity and how much of it is regulated by cells autonomously is unclear. In this study, we discovered that absence of the lipid regulator , a functional ortholog of the peroxisome proliferator-activated receptor (PPAR) in , resulted in defective pathogen avoidance behavior against (PA14).
View Article and Find Full Text PDFThe phosphatidylinositol transfer protein PITP-1 facilitates fast recovery of eating behavior after hypoxia in the nematode Caenorhabditis elegans.
FASEB J
January 2021
Department of Biochemistry and Molecular Biology, Faculty of Medicine, IMRIC, The Hebrew University of Jerusalem, Jerusalem, Israel.
Among the fascinating adaptations to limiting oxygen conditions (hypoxia) is the suppression of food intake and weight loss. In humans, this phenomenon is called high-altitude anorexia and is observed in people suffering from acute mountain syndrome. The high-altitude anorexia appears to be conserved in evolution and has been seen in species across the animal kingdom.
View Article and Find Full Text PDFThe URX oxygen-sensing neurons in s are ciliated.
MicroPubl Biol
September 2020
Brandeis University, Waltham, MA 02454.
A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.
PLoS Genet
June 2018
Department of Genetics, Harvard Medical School and Boston Children's Hospital, Boston MA, United States of America.
Article Synopsis
- The study investigates the development of URX sensory dendrites in C. elegans and identifies distinct genetic mechanisms affecting their morphogenesis, specifically focusing on the role of MAPK-15 and SMA-1.
- Disruption of these genes leads to adult dendrites overextending well beyond normal length, contrasting with earlier findings on ciliated dendrites that promote growth during embryogenesis.
- The research suggests that mechanisms governing dendrite growth differ between developmental stages, highlighting a local regulatory role for MAPK-15 and implicating GCY-35 in controlling the structural integrity of sensory compartments at the dendrite endings.
Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans.
PLoS Genet
March 2018
Department of Molecular Medicine and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, United States of America.
The mechanisms by which the sensory environment influences metabolic homeostasis remains poorly understood. In this report, we show that oxygen, a potent environmental signal, is an important regulator of whole body lipid metabolism. C.
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