AI Article Synopsis
- The study examined infection rates of Clostridium difficile (CDI) at Leipzig University Hospital from 2013 to 2019, using multivariate linear regression analysis.
- Ceftriaxone was identified as the only independent predictor for the incidence of CDI, indicating a significant link between its use and infection rates.
- The research highlights the importance of understanding the pharmacokinetic and pharmacodynamic properties of antibiotics, particularly ceftriaxone's biliary excretion, when evaluating their risk of promoting CDI.
Article Abstract
We analyzed infection (CDI) rates and various antimicrobials' application densities from 2013 to 2019 at Leipzig University Hospital, Germany, by using multivariate linear regression. Ceftriaxone application was the only independent predictor of CDI incidence. Thus, antibiotics' specific pharmacokinetic and pharmacodynamic properties such as biliary excretion of ceftriaxone in its active form should be considered when determining their potential to cause CDI.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518363 | PMC |
| http://dx.doi.org/10.1093/ofid/ofaa312 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments.
PLoS Biol
January 2025
Department of Biophysics, University of Michigan, Ann Arbor, Michigan, United States of America.
As failure rates for traditional antimicrobial therapies escalate, recent focus has shifted to evolution-based therapies to slow resistance. Collateral sensitivity-the increased susceptibility to one drug associated with evolved resistance to a different drug-offers a potentially exploitable evolutionary constraint, but the manner in which collateral effects emerge over time is not well understood. Here, we use laboratory evolution in the opportunistic pathogen Enterococcus faecalis to phenotypically characterize collateral profiles through evolutionary time.
View Article and Find Full Text PDFMeningitis due to Gemella sp. in a patient with severe ENT conditions: case report and review of the literature.
Ann Clin Microbiol Antimicrob
December 2024
Laboratoire de Microbiologie, Centre Hospitalier de Valenciennes, Valenciennes, F-59300, France.
In June 2022, a 73-year-old man with a history of laryngeal and esophageal carcinoma was admitted to the emergency unit with sudden fever, confusion, and general condition deterioration. Initial assessments showed a fever of 38.5 °C, elevated C-reactive protein (CRP) at 209 mg/L, and a neutrophil count of 10.
View Article and Find Full Text PDFAcute Pyelonephritis Complicated With Spontaneous Subcapsular Renal Hematoma: A Case Report.
Cureus
November 2024
Internal Medicine, Centro Hospitalar de Trás-Os-Montes e Alto Douro, Vila Real, PRT.
Spontaneous subcapsular renal hematoma is a rare condition defined as spontaneous hemorrhage confined to the subcapsular and/or perirenal space. Its etiology can vary, ranging from renal tumors to vascular diseases, renal cysts, or infections. Here, we report the case of a 54-year-old male who presented to the emergency department with a two-day history of abdominal pain and fever.
View Article and Find Full Text PDFErysipelothrix rhusiopathiae-associated bloodstream infection in a patient with systemic lupus erythematosus: a case report and literature review.
Access Microbiol
November 2024
Division of Infectious Diseases, Surrey Memorial Hospital, Fraser Health, Surrey, British Columbia, Canada.
Systemic human infections caused by have been increasingly reported especially within immunocompromised hosts and those with significant occupational exposure to livestock and aquatic animals. We report a case of bacteraemia in a patient with systemic lupus erythematosus (SLE) and present a literature review on clinical outcomes and microbiologic diagnosis for this organism. A 43-year-old female patient was reporting a 1-month history of intermittent fevers.
View Article and Find Full Text PDFCeftriaxone encephalopathy in a very elderly dialysis patient.
CEN Case Rep
December 2024
Department of Nephrology and Hypertension, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.
Ceftriaxone is widely used clinically but it can potentially cause ceftriaxone encephalopathy in individuals who are on dialysis. We describe ceftriaxone encephalopathy in a dialysis patient. The 87-year-old Japanese woman had a 9-year dialysis history.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!