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Central Nervous System Metastases in Breast Cancer.
Curr Treat Options Oncol
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Breast Oncology Program, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Breast cancer metastasizing to the central nervous system (CNS) encompasses two distinct entities: brain metastases involving the cerebral parenchyma and infiltration of the leptomeningeal space, i.e., leptomeningeal disease.
View Article and Find Full Text PDFTriple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models.
Clin Cancer Res
December 2024
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma that develops sporadically or in Neurofibromatosis type 1 patients. Its development is marked by the inactivation of specific tumor suppressor genes (TSGs): NF1, CDKN2A and SUZ12EED (Polycomb Repressor Complex 2). Each TSG loss can be targeted by particular drug inhibitors and we aimed to systematically combine these inhibitors, guided by TSG inactivation status, to test their precision medicine potential for MPNSTs.
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Alzheimers Dement
December 2024
Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Background: In Chile, the cases of cognitive impairment and dementia are on the rise and are expected to triple by 2050. Additionally, older adults face life changes that may contribute to depression onset. We studied the relationship between cognitive impairment (CI), functional decline (FD) and depression with the risk of all-cause and cardiovascular event mortality in the Chilean population aged ≥60 years.
View Article and Find Full Text PDFSafety and efficacy of the automated suture system in valvular heart surgery: a multicenter, prospective registry.
J Cardiovasc Surg (Torino)
December 2024
Department of Cardiovascular and Thoracic Surgery, Dijon University Hospital, Dijon, France.
Background: In the last years, the Cor-Knot device has been increasingly used in heart valve surgery. Our aim was to investigate the incidence of valvular complications in patients who underwent valvular surgery using the Cor-Knot device in multicentric cohorts at one-year follow-up.
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Developing Topics.
Alzheimers Dement
December 2024
Neurology Department, Duke University, Durham, NC, USA.
Background: APOE4 leads to increased neuroinflammation, neurocognitive decline, increased risk of Alzheimer's disease, and may be associated with increased delirium risk. However, the safety and feasibility of pharmacologic modulation of APOE to prevent neuroinflammation and postoperative delirium is unclear.
Methods: We performed a Phase II, triple blind, escalating dose, randomized controlled trial to determine the safety, feasibility, and efficacy of the APOE mimetic peptide CN-105 for preventing postoperative neuroinflammation and delirium.
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