This study presents an approach for eutrophication evaluation based on the technique for order preference by similarity to an ideal solution (TOPSIS) method and Monte Carlo simulation (MCS). The MCS is employed to produce a normally distributed dataset based on the observed data while the TOPSIS method and membership function are used to evaluate the level of eutrophication. Herein, a eutrophication problem in Lake Erhai is evaluated to check the performance of the proposed approach. The evaluation results were consistent with the real situation when the coefficient P in the membership function is equal to 1. Moreover, the developed approach is able to (i) deal with evaluation items with inherent fuzziness and uncertainties, (ii) improve the reliability of evaluation results via MCS, and (iii) raise the tolerance to errors in measured data. A global sensitivity analysis indicated that the potassium permanganate index (COD) and Secchi disc (SD) are the most sensitive factors in the developed approach. Finally, a range for the coefficient P value in the membership function was recommended.
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http://dx.doi.org/10.1016/j.watres.2020.116437 | DOI Listing |
Front Immunol
January 2025
Department of Neurosciences, University of Padua, Padua, Italy.
Pediatric-Onset Multiple Sclerosis (POMS) is characterized by both white and grey matter inflammation, as well as by a higher risk of long-term physical and cognitive disability. The peculiar immunopathogenic mechanisms of POMS suggests that the use of induction therapies, including alemtuzumab (ALTZ), might be a promising approach, at least for postpuberal (> 11 yo) POMS. Although no data on the use of induction therapies in POMS are available from clinical trials currently, case series or case reports on the effect of alemtuzumab (ALTZ) have been recently published.
View Article and Find Full Text PDFOrphanet J Rare Dis
January 2025
Paediatric Orthopaedics, Deformity Reconstruction and Foot Surgery, General Orthopaedics and Tumour Orthopaedics, Muenster University Hospital, Albert-Schweitzer-Campus 1, Muenster, 48149, Germany.
Background: Sprengel deformity is a rare congenital malformation of the scapula defined by malposition during embryonic development. Affected individuals have limited range of motion of the shoulder and torticollis. Surgical reconstruction is an option to treat patients with severe deformity and functional impairment.
View Article and Find Full Text PDFNature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFSleep Breath
January 2025
Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Purpose: The expression of the respiratory events in OSA is influenced by different mechanisms. In particular, REM sleep can highly increase the occurrence of events in a subset of OSA patients, a condition dubbed REM-OSA (often defined as an AHI 2 times higher in REM than NREM sleep). However, a proper characterization of REM-OSA and its pathological sequelae is still inadequate, partly because of limitations in the current definitions.
View Article and Find Full Text PDFCurr Res Toxicol
December 2024
University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL 23826, United States.
Opioids have been the primary method used to manage pain for hundreds of years, however the increasing prescription rate of these drugs in the modern world has led to a public health crisis of overdose related deaths. Naloxone is the current standard treatment for opioid overdose rescue, but it has not been fully investigated for potential off-target toxicity effects. The current methods for pharmaceutical development do not correlate well with pre-clinical animal studies compared to clinical results, creating a need for improved methods for therapeutic evaluation.
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