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Association between lipid profile and endothelial dysfunction as assessed by the reactive hyperemia index. | LitMetric

AI Article Synopsis

  • The study focused on the relationship between endothelial dysfunction (ED) and atherosclerotic risk factors, assessed through the reactive hyperemia index (RHI) in patients undergoing coronary angiography (CAG).
  • A total of 191 patients were analyzed, dividing them into ED and non-ED groups based on RHI scores; the ED group was older and had a higher LDL-C to HDL-C ratio.
  • Key findings revealed that older age and a higher LDL-C/HDL-C ratio were significant independent markers of ED, with HDL-C also being an important factor in patients on statin treatment.

Article Abstract

Introduction: We investigated the associations between endothelial dysfunction (ED) as evaluated by the reactive hyperemia index (RHI) obtained using Endo-PAT2000® and atherosclerotic risk factors in patients who underwent coronary artery angiography (CAG).

Methods: The subjects consisted of 191 patients who were clinically suspected to have CAD and underwent CAG, and in whom we could perform Endo-PAT2000®. We divided the patients into ED (RHI<1.67, n = 71) and non-ED (RHI≥1.67, n = 120) groups.

Results: The ED group was significantly older and showed a higher ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) (L/H) than the non-ED group. A multivariate logistic regression analysis was performed to examine the associations between the presence of ED and age, gender, and BMI in addition to L/H. Age [odds ratio (OR) = 1.03, = .02] and L/H (OR = 1.64, = .01) were identified as significant independent markers of the presence of ED. Next, we divided 122 patients with statin treatment into ED (n = 40) and non-ED (n = 82) groups. The ED group tended to have higher L/H and lower HDL-C than the non-ED group. HDL-C (OR = 0.95, = .01) and age (OR = 1.05, = .04) were identified as independent markers of the presence of ED.

Conclusions: L/H was an independent marker of the presence of ED in patients without dyslipidemia. In addition, among patients with statin treatment, HDL-C was an independent marker of the presence of ED.

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Source
http://dx.doi.org/10.1080/10641963.2020.1825725DOI Listing

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