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CAR-T entering a new "phase": Improving CAR-T function by harnessing phase separation.
Cancer Res
January 2025
Yale University, New Haven, CT, United States.
Biomolecular condensation has emerged as a general principle in organizing biological processes, including immune response. Xu and colleagues recently reported that the cytoplasmic tail of the CD3ɛ subunit of TCR complex, when fused to CAR, can promote CAR condensation by liquid-liquid phase separation. Through sequence engineering, the authors identified modified CD3ɛ sequences that enhance the maturation of the immunological synapse and co-receptor signaling, leading to an improvement of cytotoxicity in vitro and anti-tumor effects in mouse xenograft models.
View Article and Find Full Text PDFBreaking the Rhythm: Harnessing the Menstrual Cycle for Better Chemotherapy.
Cancer Res
January 2025
Swiss Federal Institute of technology in Lausanne, Lausanne, Vaud, Switzerland.
A recent publication by Bornes and colleagues explored the impact of the estrous cycle on mammary tumor response to neoadjuvant chemotherapy (NAC). Using genetically engineered mouse models, Bornes and colleagues revealed that chemotherapy is less effective when initiated during the diestrus stage compared to during the estrus stage. A number of changes during diestrous were identified that may reduce chemosensitivity of mammary tumors: an increased mesenchymal state of breast cancer cells during diestrous, decreased blood vessel diameters, and higher numbers of macrophages in the tumor microenvironment.
View Article and Find Full Text PDFThe ubiquity of countertransferential and other personal responses in progression deliberations.
Int J Psychoanal
December 2024
Training and Supervising Analyst, Faculty and former Chair, Student Progression Committee, Psychoanalytic Association of New York (PANY) affiliated with NYU Grossman School of Medicine, New York, NY, USA.
Countertransferential and other types of personal responses to candidates are inevitable among psychoanalytic educators, whether they be supervisors, progression advisors, the progression committee as a whole, or course instructors. Nonetheless many educators remain unaware of these phenomena - despite the robust literature on this subject in supervisors - perhaps because we do not like to think of ourselves as having potentially deleterious personal reactions to younger colleagues with whom we have significant and highly valued relationships. This paper emphasizes the role of such phenomena in progression advisors' deliberations about candidates' development, as well as in the committee as a whole - a subject not addressed in the literature.
View Article and Find Full Text PDFOptimal timing for lithium levels.
F1000Res
January 2025
Departments of Psychiatry, Neurology, Radiology, and Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO, 63110, USA.
Reddy and Reddy (2014) discuss the optimal timing for lithium levels in patients taking once-daily extended-release lithium formulations. They argue for blood sampling 24 h after the previous dose rather than the standard 12 h. I interpret the data quite differently.
View Article and Find Full Text PDFThe impact of collaborative atmosphere on innovative work behavior of college teachers, North China.
Front Psychol
January 2025
School of Marxism, Hengshui University, Hengshui, Hebei, China.
Innovation and progress serve as the driving forces behind national development. Universities, with their comprehensive academic systems and robust research capabilities, undoubtedly play a crucial role in fostering student innovation and advancing faculty research innovation. This study aims to explore the relationship between the collaborative climate and innovative work behavior of university educators, as well as the mediating effect of knowledge sharing, in order to provide an important theoretical basis for universities to better promote innovative work behavior.
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