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| http://dx.doi.org/10.1093/synbio/ysz007 | DOI Listing |
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Why do marionette lines appear? Exploring the anatomical perspectives and role of thread-based interventions.
Skin Res Technol
April 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
The pathogenesis of marionette lines involves a complex interplay of anatomical, physiological, and age-related factors leading to the development of wrinkles around the oral commissures. This exploration delves into the distinct anatomical predispositions observed among different ethnicities, emphasizing the role of compact modiolus structures and muscle compositions. Notably, individuals of East Asian descent exhibit inherent facial structures that predispose them to pronounced sagging around the oral commissures during aging.
View Article and Find Full Text PDFDesign of Four Small-Molecule-Inducible Systems in the Yeast Chromosome, Applied to Optimize Terpene Biosynthesis.
ACS Synth Biol
April 2023
Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, 500 Technology Square, Cambridge, Massachusetts 02139, United States.
The optimization of cellular functions often requires the balancing of gene expression, but the physical construction and screening of alternative designs are costly and time-consuming. Here, we construct a strain of that contains a "sensor array" containing bacterial regulators that respond to four small-molecule inducers (vanillic acid, xylose, aTc, IPTG). Four promoters can be independently controlled with low background and a 40- to 5000-fold dynamic range.
View Article and Find Full Text PDFBridging scales between solid mechanics and surface chemistry.
Sci Rep
June 2022
FEMTO-ST Institute, CNRS-UMR 6174/UBFC, 24 chemin de l'Épitaphe, 25030, Besançon, France.
A continuum mechanics framework is used herein to model the strains induced in a micromechanical structure by surface phenomena such as adsorption. The resulting picture significantly differs from those of a liquid under surface tension. Considering a solid isotropic elastic material, it is shown that a sphere undergoes a non uniform deformation under surface adsorption.
View Article and Find Full Text PDFTranscriptional Tuning of Mevalonate Pathway Enzymes to Identify the Impact on Limonene Production in .
ACS Omega
June 2022
Biomedical Engineering Department, Boston University, Boston, Massachusetts 02215, United States.
Heterologous production of limonene in microorganisms through the mevalonate (MVA) pathway has traditionally imposed metabolic burden and reduced cell fitness, where imbalanced stoichiometries among sequential enzymes result in the accumulation of toxic intermediates. Although prior studies have shown that changes to mRNA stability, RBS strength, and protein homology can be effective strategies for balancing enzyme levels in the MVA pathway, testing different variations of these parameters often requires distinct genetic constructs, which can exponentially increase assembly costs as pathways increase in size. Here, we developed a multi-input transcriptional circuit to regulate the MVA pathway, where four chemical inducers, l-arabinose (Ara), choline chloride (Cho), cuminic acid (Cuma), and isopropyl β-d-1-thiogalactopyranoside (IPTG), each regulate one of four orthogonal promoters.
View Article and Find Full Text PDFAn Objective, Quantitative, Dynamic Assessment of Hyaluronic Acid Fillers That Adapt to Facial Movement.
Plast Reconstr Surg
February 2020
From the Division of Plastic Surgery, University of Pennsylvania; the Division of Dermatology, University of Toronto; private practice; the Division of Dermatology, Women's College Hospital; Cosmetic Dermatology; and Galderma Laboratories, L.P.
Background: Objective dynamic assessments are central to the evaluation of facial rejuvenation treatments. This study used three-dimensional digital stereophotogrammetry to generate a quantitative dynamic assessment of facial strain and hyaluronic acid filler efficacy.
Methods: Thirty women (aged 41 to 65 years) with moderate to severe bilateral nasolabial folds and marionette lines received Restylane Refyne, Restylane Defyne, or both, and were compared to a "younger" untreated group (n = 20; aged 25 to 35 years).
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