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Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients. | LitMetric

Evaluation of etiology and pregnancy outcome in recurrent miscarriage patients.

Saudi J Biol Sci

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Published: October 2020

AI Article Synopsis

  • The study evaluated the causes and outcomes of recurrent miscarriage in 280 women, focusing on various medical tests and factors influencing pregnancy loss.
  • Endocrinological disorders were identified as the primary cause, contributing to 39% of cases, while a significant 40% of cases were found to be idiopathic with no identified cause.
  • After treatment, which included a combination of therapies based on individual etiologies, a successful live birth rate of 75.7% was achieved among the participants.

Article Abstract

The purpose of this study was to evaluate etiology and pregnancy outcome of recurrent miscarriage women. The enrolled patients (280) were evaluated for Triiodothyronine, Thyroxine, Thyroid stimulating hormone, prolactin, chromosomal analysis, Haemoglobin A1C, blood sugar, Magnetic resonance imaging, 3D-ultrasound, auto-antibodies profile (antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, antinuclear antibodies, anti-thyroid antibodies and β2 glycoprotein1), torch profile (Toxoplasmo gondii, rubella, cytomegalo virus and herpes simplex virus), blood vitamin D3 levels, psychological factors, Body mass index and thrombotic factors (protein S and C deficiency, Prothrombin G20210A mutation, anti-thrombin III, Factor V Leiden and Methylenetetrahydrofolate reductase mutation), uterosalpingography (hysteronsalpingography) and hysteroscopy. The therapeutic regimens either singly or combined were employed for the treatment of recurrent miscarriage patients on the basis of etiology (single or multiple) and include intravenous immunoglobulin, low molecular weight heparin, low dose aspirin, levothyroxine, progesterone, folic acid, human chorionic gonadotrophin, vitamin D3, psychotherapy, genetic counselling. However, patients with idiopathic recurrent miscarriage were treated with progesterone supplementation, anticoagulation and/or immune modulatory agents. The incidence of primary recurrent miscarriage was highest and most of the women experienced recurrent miscarriage during first trimester. Endocrinological disorders (39%) were found as the major pathological factor for recurrent miscarriage. Other factors include uterine abnormalities (5.7%), vitamin D3 deficiency (3.5%), psychological factors (3.2%) infection (3.6%), autoimmune abnormalities (1.8%) and protein S deficiency (1.8%). However, 40% cases were idiopathic. The overall live birth rate achieved after the management of recurrent miscarriage patients was 75.7%. Enocrinopathy was the major cause of recurrent miscarriage. The overall live birth rate achieved was 75.7% with highest pregnancy outcome in secondary recurrent miscarriage patients after the management.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499272PMC
http://dx.doi.org/10.1016/j.sjbs.2020.06.049DOI Listing

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