Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication.

Trends Genet

The Wellcome Centre for Integrative Parasitology, University of Glasgow, Institute of Infection, Immunity and Inflammation, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK. Electronic address:

Published: January 2021

AI Article Synopsis

  • Genomes are dynamic, undergoing changes that influence cell behavior and drive evolution rather than being static information stores.
  • Kinetoplastids, a type of eukaryotic microbe, exhibit significant read-write genome activities that can impact vital biological functions like adapting to hosts.
  • The text explores adaptive genome variations in the kinetoplastid parasites Trypanosoma brucei and Leishmania, highlighting recent research that connects these variations to their unique genome replication strategies.

Article Abstract

The genomes of all organisms are read throughout their growth and development, generating new copies during cell division and encoding the cellular activities dictated by the genome's content. However, genomes are not invariant information stores but are purposefully altered in minor and major ways, adapting cellular behaviour and driving evolution. Kinetoplastids are eukaryotic microbes that display a wide range of such read-write genome activities, in many cases affecting critical aspects of their biology, such as host adaptation. Here we discuss the range of read-write genome changes found in two well-studied kinetoplastid parasites, Trypanosoma brucei and Leishmania, focusing on recent work that suggests such adaptive genome variation is linked to novel strategies the parasites use to replicate their unconventional genomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213392PMC
http://dx.doi.org/10.1016/j.tig.2020.09.002DOI Listing

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