This study presents a novel approach for the early detection of mild cognitive impairment (MCI) and mild Alzheimer's disease (mAD) in the elderly. Participants were 25 elderly controls (C), 25 clinically diagnosed MCI and 25 mAD patients, included after a clinical diagnosis validated by CT or MRI and cognitive tests. Our linguistic protocol involved three connected speech tasks that stimulate different memory systems, which were recorded, then analyzed linguistically by using the PRAAT software. The temporal speech-related parameters successfully differentiate MCI from mAD and C, such as speech rate, number and length of pauses, the rate of pause and signal. Parameters pauses/duration and silent pauses/duration linearly decreased among the groups, in other words, the percentage of pauses in the total duration of speech continuously grows as dementia progresses. Thus, the proposed approach may be an effective tool for screening MCI and mAD.
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http://dx.doi.org/10.1080/02699206.2020.1827043 | DOI Listing |
Neurol Int
November 2024
Complex Unit of Geriatrics, Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy.
Background: The study aimed to identify Mild Cognitive Impairment (MCI) as an alert clinical manifestation of increased probability of major acute vascular events (MVEs), such as Ischemic Stroke and heart attack.
Methods: In a longitudinal study, 181 (M = 81, F = 100; mean age of 75.8 ± 8.
CNS Neurosci Ther
April 2024
Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Background: Medial temporal lobe atrophy (MTA) is a diagnostic marker for mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the accuracy of quantitative MTA (QMTA) in diagnosing early AD is unclear. This study aimed to investigate the accuracy of QMTA and its related components (inferior lateral ventricle [ILV] and hippocampus) with MTA in the early diagnosis of MCI and AD.
Methods: This study included four groups: normal (NC), MCI stable (MCIs), MCI converted to AD (MCIs), and mild AD (M-AD) groups.
J Alzheimers Dis
July 2023
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Altered glutamatergic neurotransmission may contribute to impaired default mode network (DMN) function in Alzheimer's disease (AD). Among the DMN hub regions, frontal cortex (FC) was suggested to undergo a glutamatergic plasticity response in prodromal AD, while the status of glutamatergic synapses in the precuneus (PreC) during clinical-neuropathological AD progression is not known.
Objective: To quantify vesicular glutamate transporter VGluT1- and VGluT2-containing synaptic terminals in PreC and FC across clinical stages of AD.
NEJM Evid
December 2022
Patrick Merrell is a freelance puzzle maker, graphic artist, writer, illustrator, cartoonist (including as one of MAD magazine's "Usual Gang of Idiots"), and photographer - all in about equal doses.
Surprise! According to findings in the article entitled "Computerized Games versus Crosswords Training in Mild Cognitive Impairment," now published in , solving crosswords had a more beneficial effect on older adults with mild cognitive impairment (MCI) than training with an array of Web-based brain games. The researchers had hypothesized just the opposite outcome, in part, on the basis of the findings of a 2015 study involving cognitively intact participants of a greater age range (18-80 years of age in the earlier study vs. 55-95 years of age in the current study).
View Article and Find Full Text PDFLife (Basel)
June 2022
Faculty of Medicine, Institute of Orthodontics, University of Coimbra, 3000-075 Coimbra, Portugal.
Background: Mandibular Advancement Devices (MADs), inserted in non-surgical treatments for obstructive sleep apnea and hypopnea syndrome (OSAHS), are used intra-orally during the sleep period, with the aim of promoting mandibular protrusion. The aim of the study is to analyze the changes in the upper airway after the use of an MAD in the treatment of OSAHS.
Methods: 60 patients diagnosed with OSAHS, as established by the Sleep Medicine Service, underwent treatment with the Silensor SL device at the Stomatology Service of the University Hospital Center of Coimbra, from January 2018 to January 2019.
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